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首页> 外文期刊>AIDS Research and Human Retroviruses >Recent HIV type 1 infection among participants in a same-day mobile testing pilot study in Zimbabwe.
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Recent HIV type 1 infection among participants in a same-day mobile testing pilot study in Zimbabwe.

机译：在津巴布韦进行的一项当天流动测试试点研究中，参与者中最近的HIV 1型感染。

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We estimated HIV-1 incidence and characterized risk factors associated with recent infection among participants of a mobile HIV voluntary counseling and testing (VCT) pilot program in two communities in Zimbabwe (N = 1096). HIV-1 infection was diagnosed using a parallel rapid testing algorithm. Recent HIV-1 infections were characterized using the BED immunoglobulin G capture enzyme immunoassay (BED-CEIA). HIV prevalence was 28.9% overall and nearly twice as high in women compared to men (39.5% vs. 21.4%, p < 0.001). HIV-1 incidence was 1.91% and was comparable between men and women (1.99% vs.1.88%; p = 0.626). Although not significant, the proportion of recent infections among all infections was highest among persons ages 25 to 34 years old (10.5%) for both men (11.9%) and women (9.2%). Persons recently infected compared to those with long-term infections were more likely to report STD symptoms (33% vs. 13%; OR = 3.2; p = 0.075) and prior STD treatment (13% vs. 6%; OR = 3.4; p = 0.187) in the previous 6 months. There were no associations found between recent versus long-term HIV infection status and perceived risk or expectation of negative test results. Recent HIV-1 infection detection among mobile VCT participants is a valuable measure for tracking the spread of the epidemic among persons who might otherwise not have access to HIV testing due to practical and logistical barriers. Mobile VCT presents opportunities to expand HIV testing services and evaluate at-risk populations within community settings. Given the challenges of longitudinal cohort studies, recent infection may be a practical endpoint for community-based prevention intervention trials employing mobile testing.
机译：我们估计了津巴布韦两个社区的流动HIV自愿咨询和测试（VCT）试点项目参与者中HIV-1的发病率和与近期感染相关的特征性危险因素（N = 1096）。使用并行快速测试算法诊断出HIV-1感染。使用BED免疫球蛋白G捕获酶免疫分析（BED-CEIA）对最近的HIV-1感染进行了表征。总体上，艾滋病毒感染率为28.9％，而女性的艾滋病毒感染率是男性的两倍（39.5％对21.4％，p <0.001）。 HIV-1的发生率为1.91％，男女之间可比（1.99％对1.88％; p = 0.626）。尽管影响不大，但在所有感染中，男性（11.9％）和女性（9.2％）中最近感染的比例在25至34岁的人群中最高（10.5％）。与长期感染者相比，近期感染者更容易报告性病症状（33％比13％; OR = 3.2; p = 0.075）和先前的性病治疗（13％比6％; OR = 3.4; p = 0.187）的前6个月。在近期和长期的HIV感染状况与检测结果阴性或预期的风险之间没有关联。最近，在流动VCT参与者中检测到HIV-1感染是追踪流行病在因实际和后勤障碍而可能无法获得HIV检测的人群中传播情况的一项有价值的措施。移动VCT提供了扩展艾滋病毒检测服务和评估社区环境中高危人群的机会。考虑到纵向队列研究的挑战，对于使用移动测试的社区预防干预试验，近期感染可能是一个实际的终点。

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