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首页> 外文期刊>AIDS Research and Human Retroviruses >Identification of three immunologic correlates for HIV type 1 pathogenesis in youth.
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Identification of three immunologic correlates for HIV type 1 pathogenesis in youth.

机译：鉴定青年时期HIV 1型发病机制的三种免疫学相关因素。

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To evaluate the stability and heterogeneity of cytokine and chemokine profiles in 80 youth with and without HIV-1 infection, we tested plasma samples at repeated visits without antiretroviral therapy. Among nine analytes that were quantified using multiplexing assays, interleukin 10 (IL-10), IL-18, and soluble CD30 persistently showed a positive correlation with HIV-1 viral load (Spearman rho = 0.40-0.59, p < 0.01 for all). A negative correlation with CD4(+) T cell counts (rho = -0.40 to -0.60, p < 0.01 for all) was also persistent for the three analytes. Analyses restricted to 48 AIDS-free youth (96 visits) yielded similar findings, as did multivariable models in which race, sex, age, body mass index, and time interval between visits were treated as covariates. These relationships reflected two novel features observed for all three analytes. First, their presence in plasma was relatively stable between visits (rho = 0.50-0.90, p < 0.03), regardless of HIV-1 infection status. Second, pairwise correlation was strong and persistent in HIV-1-seropositive youth (rho = 0.40-0.59, p < 0.01), but not in HIV-1, seronegatives (p > 0.13). Additional analytes, especially eotaxin/CCL11 and SDF-1beta/CXCL12, had no correlation with HIV-1-related outcomes despite their stability between visits. Overall, circulating IL-10, IL-18, and soluble CD30 could partially track unfavorable responses to HIV-1 infection in youth. These markers of persistent immune activation are individually and collectively indicative of HIV-1 pathogenesis.
机译：为了评估80名有或没有HIV-1感染的青年人中细胞因子和趋化因子谱的稳定性和异质性，我们在不进行抗逆转录病毒治疗的情况下反复进行了血浆样品测试。在通过多重分析定量的9种分析物中，白介素10（IL-10），IL-18和可溶性CD30持续显示与HIV-1病毒载量呈正相关（Spearman rho = 0.40-0.59，所有p <0.01） 。三种分析物与CD4（+）T细胞计数的负相关（rho = -0.40至-0.60，所有p <0.01）也一直存在。仅限于48名无艾滋病年轻人（96次就诊）的分析以及类似的多变量模型也将种族，性别，年龄，体重指数和就诊之间的时间间隔作为协变量进行了分析。这些关系反映了对所有三种分析物观察到的两个新颖特征。首先，无论HIV-1感染状况如何，在两次就诊之间血浆中它们的存在相对稳定（rho = 0.50-0.90，p <0.03）。其次，在HIV-1血清阳性的青年中，成对相关性很强且持久（rho = 0.40-0.59，p <0.01），而在血清阴性的HIV-1中则没有（p> 0.13）。尽管其他访视之间具有稳定性，但其他分析物（尤其是嗜酸性粒细胞趋化因子/ CCL11和SDF-1beta / CXCL12）与HIV-1相关结果没有相关性。总体而言，循环中的IL-10，IL-18和可溶性CD30可以部分追踪年轻人对HIV-1感染的不良反应。这些持久性免疫激活的标志物单独和共同指示了HIV-1的发病机理。

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