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首页> 外文期刊>AIDS Research and Human Retroviruses >HIV-specific gag responses in early infancy correlate with clinical outcome and inversely with viral load.
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HIV-specific gag responses in early infancy correlate with clinical outcome and inversely with viral load.

机译：婴儿早期的HIV特异性gag反应与临床结果相关，与病毒载量呈反相关。

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Many HIV-infected infants progress to AIDS during the first year of life when antiretroviral therapy (ART) is not given. The immune determinants of progression to AIDS are not known. We hypothesized that distinct HIV-specific T cell responses correlate with viral load and survival over the first year of life. Whole blood of infants at 3, 6, 9, and 12 months of age was incubated with HIV antigens Gag and Env. The frequency of specific T cells producing interferon (IFN)-gamma was then measured by flow cytometry. Viral load and CD4% in HIV(+) infants were determined at each time point. ART was not available for this population at the time of sample collection. Those infants who survived to 12 months of age (n=12) had lower viral loads and higher Gag-specific CD8(+) T cell responses at 3 months, compared with infants who died (n=8). Furthermore, the frequency of Gag-specific CD4(+) T cells correlated inversely with viral load at 3 and 6 months of age. Together these data indicate that the early presence of quantitatively higher Gag-specific T cell responses in HIV-infected infants is associated with lower viral loads and decreased mortality in the first year of life. Our data support the design of a vaccine that preferentially elicits Gag responses, which may result in lower levels of viremia and possibly improve outcome.
机译：在未进行抗逆转录病毒疗法（ART）的第一年，许多受HIV感染的婴儿会发展为AIDS。尚无发展为AIDS的免疫决定因素。我们假设不同的HIV特异性T细胞反应与生命第一年的病毒载量和存活率相关。将3、6、9和12个月大的婴儿全血与HIV抗原Gag和Env一起孵育。然后通过流式细胞术测量产生干扰素（IFN）-γ的特定T细胞的频率。在每个时间点确定HIV（+）婴儿的病毒载量和CD4％。在收集样本时，ART不适用于该人群。与死亡的婴儿（n = 8）相比，存活到12个月（n = 12）的婴儿在3个月时具有较低的病毒载量和较高的Gag特异性CD8（+）T细胞应答。此外，Gag特异性CD4（+）T细胞的频率与3个月和6个月大的病毒载量成反比。这些数据加在一起表明，在HIV感染的婴儿中早期出现定量更高的Gag特异性T细胞应答与较低的病毒载量和出生后第一年的死亡率降低有关。我们的数据支持优先引发Gag应答的疫苗设计，这可能导致较低的病毒血症水平并可能改善结果。

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