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首页> 外文期刊>Thorax: The Journal of the British Thoracic Society >Influence of excessive weight loss after gastroplasty for morbid obesity on respiratory muscle performance.
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Influence of excessive weight loss after gastroplasty for morbid obesity on respiratory muscle performance.

机译：胃膜成形术后体重减轻过度损失对呼吸肌性能的病态肥胖。

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BACKGROUND: Morbidly obese subjects are known to have impaired respiratory function and inefficient respiratory muscles. A study was undertaken to investigate the influence of excessive weight loss on pulmonary and respiratory muscle function in morbidly obese individuals who underwent gastroplasty to induce weight loss. METHODS: Twenty one obese individuals with mean (SE) body mass index (BMI) 41.5 (4.5) kg/m2 without overt obstructive airways disease (FEV1/FVC ratio > 80%) were studied before and six months after vertical banded gastroplasty. Only patients who had lost at least 20% of baseline BMI were included in the study. Standard pulmonary function tests and respiratory muscle strength and endurance were measured. RESULTS: Before operation the predominant abnormalities in respiratory function were significant reductions in lung volumes and respiratory muscle endurance and, to a lesser degree, reductions in respiratory muscle strength. All parameters increased towards normal values after weight loss with significant increases in functional residual capacity (FRC) from 84.0 (2.2) to 91.3 (2.5)% of predicted normal values (mean difference 7.3, 95% confidence interval of difference (CI) 4.2 to 10.5), total lung capacity (TLC) from 85.6 (3.0) to 93.5 (3.7)% of predicted normal values (mean difference 7.9, 95% CI 4.5 to 11.5), residual volume (RV) from 86.7 (3.1) to 96.4 (3.0) of predicted normal values (mean difference 9.7, 95% CI 5.2 to 14.1), expiratory reserve volume (ERV) from 76.6 (3.0) to 89.0 (3.4)% of predicted normal values (mean difference 12.4, 95%, CI 6.3 to 18.9), respiratory muscle strength: PImax from 92 (4.4) to 113 (4.6) cm H2O (mean difference 21, 95% CI 12.2 to 31.6), PEmax from 144 (5.6) to 166 (4.3) cm H2O (mean difference 22, 95% CI 12.9 to 32.0), and endurance: PmPeak/PImax from 56 (1.4) to 69 (2.0)% (mean difference 13, 95% CI 9.7 to 16.9). The strongest correlation was between weight loss and the improvement in respiratory muscle endurance. CONCLUSIONS: Lung volumes and respiratory muscle performance are decreased in obese individuals. Weight loss following gastroplasty is associated with improvement in lung volumes and respiratory muscle function.
机译：背景：已知病态肥胖的受试者受到呼吸功能和低效呼吸肌的损害。进行了研究，探讨了在处理胃骨膜术后病态肥胖症体中肺和呼吸肌功能过度减肥对胃膜损失的影响。方法：在垂直带状腹腔成形术后和六个月之前，研究了二十一只具有平均（SE）体重指数（BMI）41.5（4.5）kg / m 2的肥胖单位（BMI）41.5（4.5）kg / m2。只有20％的基线BMI才包含至少20％的患者。测量标准肺功能试验和呼吸肌强度和耐久性。结果：在操作之前，呼吸功能的主要异常在肺量和呼吸肌耐久性的显着降低，较小程度，降低呼吸肌力量。所有参数增加到重量损失后的正常值，其功能残留能力（FRC）从84.0（2.2）至91.3（2.5）％的预测正常值（平均差异为7.3，95％差分（CI）4.2至10.5），总肺容量（TLC）从85.6（3.0）至93.5（3.7）％预测正常值（平均差异7.9,95％CI 4.5至11.5），残余体积（RV）从86.7（3.1）到96.4（ 3.0）预测正常值（平均差异9.7,95％CI 5.2至14.1），从76.6（3.0）到89.0（3.4）％的呼气储备体积（ERV）预测正常值（平均差异12.4,95％，CI 6.3至18.9），呼吸肌强度：Pimax从92（4.4）至113（4.6）cm H 2 O（平均差21,95％CI 12.2至31.6），Pemax从144（5.6）到166（4.3）cm H 2 O（平均差异22,95％CI 12.9至32.0），耐久性：PMPEAK / PIMAX为56（1.4）至69（2.0）％（平均差异13,95％CI 9.7至16.9）。最强的相关性是减重和呼吸肌肉耐力的改善。结论：肥胖个体减少了肺体积和呼吸肌性能。腹腔成形术后的体重减轻与肺体积和呼吸肌功能的改善有关。

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