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首页> 外文期刊>AIDS Research and Human Retroviruses >Short communication: Paraoxonase 1 (PON1) in French HIV-infected patients under antiretroviral therapy: Relationship with the metabolic syndrome and inflammation
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Short communication: Paraoxonase 1 (PON1) in French HIV-infected patients under antiretroviral therapy: Relationship with the metabolic syndrome and inflammation

机译：简短交流：在接受抗逆转录病毒疗法的法国HIV感染患者中，对氧磷酶1（PON1）：与代谢综合征和炎症的关系

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摘要

Our goal was to determine if paraoxonase 1 (PON1) activity relates to the presence of metabolic syndrome (MS) and inflammation in HIV patients treated with highly active antiretroviral therapy (HAART). This was a prospective, multicenter study including 269 patients receiving HAART for at least 1 year and a maximum of 4 years. PON1 and inflammatory markers [C reactive protein (CRP), interleukin-6 (IL-6), serum amyloid A (SAA), and soluble tumor necrosis factor receptors 2 (sTNF-R2)] were compared between patients with or without MS and the association between inflammatory markers and PON1 was assessed by logistic regression analyses. MS was found in 18.2% of the patients. Inflammatory markers, with the exception of sTNF-R2, were significantly higher, while PON1 activity was significantly lower in the presence of metabolic syndrome. PON1 activity was significantly related to apolipoprotein C3, CD4 count, and sTNF-R2. It may be concluded that PON1 appears to be a marker for the metabolic syndrome in HIV-infected subjects. PON1 activity is related to dyslipidemia and the immunological status of the patients but is not fully determined by inflammation.
机译：我们的目标是确定在使用高效抗逆转录病毒疗法（HAART）治疗的HIV患者中，对氧磷酶1（PON1）活性是否与代谢综合征（MS）和炎症相关。这是一项前瞻性，多中心研究，包括269例接受HAART至少1年且最多4年的患者。在有或没有MS的患者中，比较了PON1和炎症标志物[C反应蛋白（CRP），白介素6（IL-6），血清淀粉样蛋白A（SAA）和可溶性肿瘤坏死因子受体2（sTNF-R2）]。通过logistic回归分析评估炎症标志物与PON1之间的关联。在18.2％的患者中发现了MS。在存在代谢综合征的情况下，除sTNF-R2外，炎症标志物明显较高，而PON1活性则明显较低。 PON1活性与载脂蛋白C3，CD4计数和sTNF-R2显着相关。可以得出结论，PON1似乎是HIV感染者体内代谢综合征的标志物。 PON1活性与血脂异常和患者的免疫状况有关，但不能完全由炎症决定。

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