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HIV prevalence and incidence among women at higher risk of infection in Addis Ababa, Ethiopia

机译：埃塞俄比亚亚的斯亚贝巴较高感染风险女性的艾滋病毒流行率和发病率

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This study aimed to estimate HIV incidence among women at higher HIV risk in Addis Ababa, Ethiopia using cross-sectional data. To refine the estimate, we sought to determine a local correction factor by estimating a false recent rate for the BED assay. The overall study had two parallel phases: cross-sectional incidence and BED false recent (BED FR). A total of 1856 women at higher HIV risk were enrolled into the cross-sectional phase. For the BED FR, 500 women and 70 men with known HIV infection of greater than 12 months were enrolled. Rapid HIV tests were used to assess participant HIV status. Samples from women with positive results on HIV rapid testing were then analyzed using the BED assay to determine incident HIV infections. The overall HIV prevalence was 11.3%, with women greater than 25 years old having a higher prevalence (26.5% vs. 7.9% for younger women). The overall unadjusted HIV incidence was 3.3%. The estimated HIV incidence was 2.6% when adjusted using the locally derived false recent rate of 3.5%. Similar incidence rates were found between the younger and older age groups. This is one of the first field-based studies of HIV incidence in Ethiopia; it demonstrates that there is sufficient incidence to warrant further HIV prevention efforts among women at higher risk of HIV infection.
机译：这项研究的目的是使用横断面数据估算埃塞俄比亚亚的斯亚贝巴的高艾滋病毒风险妇女中的艾滋病毒发生率。为了完善估计，我们试图通过估计BED分析的近期错误率来确定局部校正因子。总体研究分为两个平行阶段：横断面发病率和近期BED假（BED FR）。共有1856名HIV感染风险较高的妇女进入横断面研究阶段。对于BED FR，招募了500名女性和70名男性，已知感染艾滋病毒的时间均超过12个月。快速的HIV检测用于评估参与者的HIV状况。然后，使用BED分析法分析了在HIV快速检测中呈阳性结果的女性样本，以确定是否感染了HIV。总体艾滋病毒感染率为11.3％，其中25岁以上的女性患病率更高（26.5％，而年轻女性为7.9％）。总体未经调整的艾滋病毒发生率为3.3％。如果使用本地衍生的3.5％的近期误报率进行调整，则估计的HIV发生率为2.6％。年轻人和老年人之间的发病率相似。这是埃塞俄比亚首批基于现场的艾滋病毒感染率研究。它表明，有足够的发病率，需要在艾滋病毒感染风险较高的妇女中进一步开展艾滋病毒预防工作。

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