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Dynamics of HIV type 1 recombination following superinfection

机译:重叠感染后HIV 1型重组的动力学

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There are currently few detailed studies describing HIV-1 recombination events or the potential impact of recombination on drug resistance. We describe here the viral recombination dynamics in a drug-naive patient initially infected with a circulating recombinant form 19 (CRF19) virus containing transmitted drug resistance mutations followed by superinfection with "wild-type" subtype B virus. Single genome analysis showed replacement of the primary CRF19 virus by recombinants of the CRF19 virus and the superinfecting subtype B virus. The CRF19/B recombinant virus dominating after superinfection had lost drug resistance mutations and at no time was the superinfecting subtype B variant found to be dominant in blood plasma. Furthermore, the detection of recombinant viruses in seminal plasma indicates the potential for onward transmission of these strains.
机译:目前很少有详细的研究描述HIV-1重组事件或重组对耐药性的潜在影响。我们在这里描述了最初用循环重组形式19(CRF19)病毒感染的无药物治疗患者的病毒重组动力学,该病毒包含传播的耐药性突变,然后再感染“野生型” B亚型病毒。单基因组分析表明,原代CRF19病毒被CRF19病毒和超感染B型亚型病毒的重组体替代。在超级感染后占主导地位的CRF19 / B重组病毒失去了耐药性突变,而且从来没有发现超级感染B型亚型在血浆中占主导地位。此外,在精浆中检测到重组病毒表明这些菌株可能继续传播。

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