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Differential regulatory T cell activity in hiv type 1-exposed seronegative individuals

机译：HIV 1型血清阴性个体的差异调节性T细胞活性

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摘要

The potential role of conventional and regulatory T cells (Tregs) in protection from HIV-1 infection remains unclear. To address this question, we analyzed samples from 129 HIV-1-exposed seronegative individuals (HESN) from an HIV-1-serodiscordant couples cohort. To assess the presence of HIV-specific T cell responses and Treg function, we measured the proliferation of T cells in response to HIV-1 peptide pools in peripheral blood mononuclear cells (PBMCs) and PBMCs depleted of Tregs. We identified HIV-specific CD4+ and CD8+ T cell responses and, surprisingly, the overall CD4+ and CD8+ T cell response rate was not increased when Tregs were removed from cell preparations. Of the 20 individuals that had HIV-1-specific CD4+ T cell responses, only eight had Tregs that could suppress this proliferation. When compared with individuals whose Tregs could suppress HIV-1-specific CD4+ T cell proliferation, individuals with Tregs unable to suppress showed a trend toward increased T cell activation and Treg frequency and a significant increase in HIV-1-specific production of microphage inflammatory protein-1β (MIP-1β) by CD4+ T cells, autocrine production of which has been shown to be protective in terms of HIV-1 infection of CD4+ T cells.
机译：尚不清楚常规和调节性T细胞（Tregs）在预防HIV-1感染中的潜在作用。为了解决这个问题，我们分析了来自HIV-1血清不协调夫妇队列的129名HIV-1暴露的血清阴性个体（HESN）的样本。为了评估HIV特异性T细胞应答和Treg功能的存在，我们测量了外周血单核细胞（PBMC）和Treg耗尽的PBMC中对HIV-1肽库的应答中T细胞的增殖。我们确定了HIV特异性CD4 +和CD8 + T细胞反应，令人惊讶的是，当从细胞制备物中去除Treg时，总体CD4 +和CD8 + T细胞反应率并未增加。在具有HIV-1特异性CD4 + T细胞反应的20个个体中，只有8个具有可抑制这种增殖的Treg。与其Treg可以抑制HIV-1特异性CD4 + T细胞增殖的个体相比，患有Treg不能抑制的个体表现出T细胞活化和Treg频率增加的趋势，并且HIV-1特异性噬菌体炎性蛋白的产生显着增加。 CD4 + T细胞的-1β（MIP-1β），自分泌产生对CD4 + T细胞的HIV-1感染具有保护作用。

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