首页> 外文期刊>AIDS Research and Human Retroviruses >Short communication: Proangiogenic hematopoietic cells in acute HIV infection
【24h】

Short communication: Proangiogenic hematopoietic cells in acute HIV infection

机译:简短交流:急性HIV感染中促血管生成的造血细胞

获取原文
获取原文并翻译 | 示例
           

摘要

Chronic HIV infection induces significant changes in the trafficking of circulating endothelial progenitor cells (EPCs). Specifically, it causes marked depletion of proangiogenic hematopoietic cells, the so-called colony-forming unit-endothelial cells (CFU-ECs). In this study we evaluated CFU-ECs in two subjects with acute HIV infection. We found that both patients already had a low CFU-EC level at the time of diagnosis. Nevertheless, after 6 months of antiretroviral therapy, the CFU-EC concentration reverted to normal values in both cases. HIV significantly depletes the CFU-EC compartment even in the early phase of infection, while 6-month therapy appears to be able to restore it.
机译:慢性HIV感染导致循环内皮祖细胞(EPC)的运输发生重大变化。具体来说,它会导致促血管生成的造血细胞(所谓的集落形成单位内皮细胞(CFU-EC))明显耗竭。在这项研究中,我们评估了两名患有急性HIV感染者的CFU-EC。我们发现,两名患者在诊断时已经具有低CFU-EC水平。然而,经过6个月的抗逆转录病毒治疗后,两种情况下CFU-EC浓度均恢复为正常值。即使在感染的早期,HIV也会显着耗尽CFU-EC隔室,而6个月的治疗似乎能够使它恢复。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号