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首页> 外文期刊>AIDS Research and Human Retroviruses >Working group consultation: Alloimmunity as a vaccine approach against HIV/AIDS: National Institutes of Health Meeting Report, May 24, 2012
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Working group consultation: Alloimmunity as a vaccine approach against HIV/AIDS: National Institutes of Health Meeting Report, May 24, 2012

机译：工作组咨询：同种免疫作为针对HIV / AIDS的疫苗方法：美国国立卫生研究院会议报告，2012年5月24日

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摘要

Alloimmunization vaccine strategies propose to avoid the problem of the extreme antigenic variability of human immunodeficiency virus (HIV) by instead focusing on the cellular antigens incorporated into HIV virions as they bud from infected cells. This report summarizes a Consultation meeting convened by the National Institute of Allergy and Infectious Diseases, National Institutes of Health on May 24, 2012. The objectives of the meeting were to (1) reach a consensus on the essential questions surrounding alloimmunization as a strategy for vaccine design against HIV, and (2) determine the experimental elements that might be needed for addressing these questions in an optimized pilot framework nonhuman primate (NHP) protocol for allogeneic immunization. The Consultation revisited the rationale and concerns of vaccination to induce allogeneic immunity, one of the most potent natural immune responses. The panelists' consensus was that a carefully designed skin graft transplant pilot experiment, in major histocompatibility complex (MHC) disparate male Mauritian cynomolgus macaques (MCM; Macaca fascicularis), would be useful for initially evaluating if alloimmunization results in an effective or even a partially effective safe AIDS vaccine. A successful NHP study for allogeneic immunization would provide further opportunities to explore vaccine-elicited immune and genetic correlates of protection against the acquisition of viral infection.
机译：同种免疫疫苗策略建议避免人类免疫缺陷病毒（HIV）的极端抗原变异性的问题，而应着重于当HIV病毒粒子从受感染细胞中萌发时掺入到其中的细胞抗原。本报告总结了2012年5月24日由美国国立卫生研究院过敏与传染病研究所召开的一次协商会议。会议的目的是（1）就围绕同种免疫作为治疗策略的基本问题达成共识。针对HIV的疫苗设计，以及（2）确定用于同种异体免疫的优化试验框架非人灵长类（NHP）方案中解决这些问题所需的实验要素。磋商会重新讨论了接种疫苗以诱导同种异体免疫（最有效的自然免疫反应之一）的理由和关注。小组成员的共识是，精心设计的异种雄性毛里求斯食蟹猕猴（MCM;猕猴猕猴）的皮肤移植物先导实验，将有助于初步评估同种免疫是否是有效甚至部分免疫有效的安全艾滋病疫苗。 NHP一项成功的异体免疫研究将为探索疫苗引发的针对获得性病毒感染的保护性免疫和遗传相关性提供进一步的机会。

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