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首页> 外文期刊>AIDS Research and Human Retroviruses >Short communication: Human immunodeficiency virus rebound in blood and seminal plasma following discontinuation of antiretroviral therapy
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Short communication: Human immunodeficiency virus rebound in blood and seminal plasma following discontinuation of antiretroviral therapy

机译：简短交流：终止抗逆转录病毒治疗后，人类免疫缺陷病毒在血液和精浆中反弹

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Although there is discordance between human immunodeficiency virus (HIV) blood plasma and seminal plasma viral loads (VL), little is known about the dynamics of VL rebound in these compartments upon discontinuation of highly active antiretroviral therapy (HAART). Therefore, we sought to examine the relationship between blood and semen VL rebound after discontinuation of HAART. Participants in this substudy were men enrolled from two centers of a multicenter, placebo-controlled randomized trial of HIV therapeutic vaccination using ALVAC with or without Remune. With at least 2 years of sustained virologic suppression and following a 20-week vaccination course, subjects underwent structured HAART interruption. Fourteen men provided semen samples. Seven to 12 weeks after HAART interruption, all 14 men had detectable blood VLs whereas 8 of 14 had detectable seminal VLs. There was a significant correlation between blood and seminal VLs (Spearman r=0.58, p=0.03) at the time of semen collection. An earlier time to detectable blood VL after HAART interruption was associated with higher seminal VL (Spearman r=-0.64, p=0.02). These findings support the compartmentalization of HIV and underscore the importance of understanding the genital tract as an HIV reservoir in the quest to minimize HIV transmission.
机译：尽管人类免疫缺陷病毒（HIV）血浆和精浆血浆病毒载量（VL）之间存在矛盾，但对于中隔高活性抗逆转录病毒疗法（HAART）时这些隔室中VL反弹的动力学知之甚少。因此，我们试图检查停药后血液与精液VL反弹之间的关系。该子研究的参与者是来自多中心安慰剂对照随机试验的两个中心的男性，该试验使用ALVAC或不使用Remune进行HIV治疗性疫苗接种。经过至少2年的持续病毒抑制，并在接种了20周的疫苗后，受试者经历了结构性的HAART中断。 14名男子提供了精液样本。 HAART中断后7至12周，所有14名男性都有可检测的血液VL，而14名男性中有8名具有可检测的精液VL。在收集精液时，血液和精液之间存在显着相关性（Spearman r = 0.58，p = 0.03）。 HAART中断后较早的可测血液VL与较高的精液VL有关（Spearman r = -0.64，p = 0.02）。这些发现支持了对艾滋病病毒的隔离，并强调了将生殖道理解为艾滋病毒储库的重要性，以期将艾滋病毒的传播降至最低。

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