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首页> 外文期刊>AIDS Research and Human Retroviruses >Partner characteristics predicting HIV-1 set point in sexually acquired HIV-1 among African seroconverters
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Partner characteristics predicting HIV-1 set point in sexually acquired HIV-1 among African seroconverters

机译：伴侣特征预测非洲血清转化者中性获取的HIV-1中的HIV-1设定点

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摘要

Plasma HIV-1 RNA set point is an important predictor of HIV-1 disease progression. We hypothesized that inoculum size and HIV-1 exposure prior to HIV-1 transmission may modulate set point. We evaluated predictors of set point among 141 African HIV-1 seroconverters and their HIV-1-infected study partners. We compared characteristics of seroconverters and their HIV-1-infected partners and HIV-1 set point. Data were from a clinical trial of genital HSV-2 suppression with acyclovir to reduce HIV-1 transmission in HIV-1 serodiscordant couples with HIV-1 transmission linkage assigned through virus sequencing. Our analysis includes data from all transmissions including those with transmission linkage to the HIV-1-infected "source partner" and those that were not linked to their HIV-1-infected study partner. In multivariable analysis, higher plasma HIV-1 in source partners was associated with higher seroconverter set point (+0.44 log10 copies/ml per log10 source partner plasma HIV-1, p0.001). In addition, bacterial vaginosis (BV) among female source partners near the time of infection was associated with higher set point in their male seroconverters (+0.49 log10, p=0.04). Source partner characteristics associated with lower set point included male circumcision (-0.63 log10, p=0.03) and assignment to acyclovir (-0.44 log 10, p=0.02). The proportion of variation in set point explained by plasma HIV-1 RNA of the source partner, after controlling for other factors, was 0.06. Source partner plasma HIV-1 level is the most significant predictor of seroconverter set point, possibly reflecting characteristics of the transmitted virus. Acyclovir use, BV among women source partners, and circumcision among male source partners may alter the set point by affecting transmitted virus inoculum in the source partners' genital compartment.
机译：血浆HIV-1 RNA设定点是HIV-1疾病进展的重要预测指标。我们假设HIV-1传播之前的接种量和HIV-1暴露可能会调节设定点。我们评估了141个非洲HIV-1血清转化者及其感染HIV-1的研究对象中设定点的预测因子。我们比较了血清转化者及其感染HIV-1的伴侣和HIV-1设定点的特征。数据来自用阿昔洛韦抑制生殖器HSV-2的临床试验，以减少HIV-1血清型夫妻中HIV-1的传播，并通过病毒测序确定HIV-1的传播联系。我们的分析包括所有传播的数据，包括与HIV-1感染的“源伴侣”具有传播联系的那些传播，以及与HIV-1感染的研究伙伴没有联系的传播。在多变量分析中，源配偶体血浆HIV-1的升高与血清转化者设定值的升高相关（每log10源配偶体血浆HIV-1 +0.44 log10拷贝/ml，p<0.001）。此外，女性感染源附近的细菌性阴道病（BV）接近感染时与男性血清转化者较高的设定点相关（+0.49 log10，p = 0.04）。与较低设定点相关的源伴侣特征包括男性包皮环切术（-0.63 log10，p = 0.03）和分配给阿昔洛韦（-0.44 log 10，p = 0.02）。控制其他因素后，由源伴侣的血浆HIV-1 RNA解释的设定点变化比例为0.06。源伴侣血浆HIV-1水平是血清转换器设定点的最重要预测指标，可能反映了传播病毒的特征。使用阿昔洛韦，女性性伴侣中的BV和男性性伴侣中的包皮环切术可能会通过影响性伴侣中生殖器隔室中传播的病毒接种物来改变设定值。

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