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首页> 外文期刊>AIDS Research and Human Retroviruses >Genetic architecture of HIV Type 1 Nef and Tat from HLA-B57-typed long-term survivors in an indian cohort of perinatally HIV-infected children
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Genetic architecture of HIV Type 1 Nef and Tat from HLA-B57-typed long-term survivors in an indian cohort of perinatally HIV-infected children

机译：来自印度围生期感染HIV的儿童队列中HLA-B57型长期幸存者的HIV 1型Nef和Tat的遗传结构

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摘要

Human immunodeficiency virus type 1 (HIV-1) viral genes nef and tat play an important role in disease progression. In this study we characterized the Nef and Tat proteins from a group of HLA-B57 typed pediatric perinatally infected long-term survivors (LTS) with ≥10 years of infection. We identified 19 therapy-naive LTS after screening 250 children from an Indian pediatric cohort. Nef and tat amplified from plasma virus showed that all the LTS harbored HIV-1 subtype C. The two B57+ children showed mutations, deletions, and insertions in experimentally defined B57 epitopes in the virus that are likely to be escape mutants. Only GW12 (GPGVRYPLTFGW) and YY9 (YTPGPGIRY) were conserved, while the remaining 90% (18/20) of the epitopes showed some degree of mutations. The most variable epitopes were RR15, SE15, QP15, KF9, HW9, YT9, and GF15. To our knowledge this is the first study from India in which characterization of Nef and Tat from LTS has led to information on genetic alterations in these genes that are associated with slow disease progression, and can provide an important lead in future studies.
机译：人类免疫缺陷病毒1型（HIV-1）病毒基因nef和tat在疾病进展中起重要作用。在这项研究中，我们从一组感染≥10年的HLA-B57型儿童围产期感染长期存活者（LTS）中鉴定了Nef和Tat蛋白。我们从印度小儿队列中筛选了250名儿童后，确定了19例未接受过治疗的LTS。从血浆病毒中扩增出的Nef和tat蛋白表明，所有LTS都具有HIV-1亚型C。这两个B57 +儿童在病毒中实验定义的B57表位中显示出突变，缺失和插入，这些表位可能是逃逸突变体。仅GW12（GPGVRYPLTFGW）和YY9（YTPGPGIRY）是保守的，而其余90％（18/20）的表位显示一定程度的突变。可变表位最多的是RR15，SE15，QP15，KF9，HW9，YT9和GF15。据我们所知，这是来自印度的第一项研究，在该研究中，通过LTS鉴定Nef和Tat导致了与这些基因的遗传改变有关的信息，这些信息与疾病进展缓慢有关，并且可以为今后的研究提供重要线索。

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