Association between tipranavir plasma levels and virological response in HIV-infected patients.

Morello J; Gasco PG; Rodriguez-Novoa S; de-Mendoza C; Blanco F; Gonzalez-Pardo G; Sanz B; Jimenez-Nacher I; Soriano V

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Association between tipranavir plasma levels and virological response in HIV-infected patients.

机译：HIV感染患者的地普那韦血浆水平与病毒学应答之间的关联。

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The impact of tipranavir plasma levels (TPV C(min)) on virological response was examined in 36 antiretroviral-experienced HIV-infected individuals. Although TPV C(min) did not predict outcome in patients with less than five or more than eight baseline TPV-associated resistance mutations, TPV C(min) values were greater in responders than in nonresponders with five to seven baseline TPV-associated resistance mutations (38.8 vs. 13.8 g/ml, p = 0.017). Thus, therapeutic drug monitoring might be helpful in ensuring a viral response in this subset of patients.

机译：在36名抗逆转录病毒经验的HIV感染者中检查了地普那韦血浆水平（TPV C（min））对病毒学应答的影响。尽管TPV C（min）不能预测基线TPV相关耐药性突变少于五个或八个的患者的预后，但应答者中的TPV C（min）值要比基线TPV相关耐药性突变有五到七个的无应答者大（38.8对13.8 g / ml，p = 0.017）。因此，治疗药物监测可能有助于确保该患者亚组的病毒反应。

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《AIDS Research and Human Retroviruses》 |2008年第3期|共3页
作者
Morello J; Gasco PG; Rodriguez-Novoa S; de-Mendoza C; Blanco F; Gonzalez-Pardo G; Sanz B; Jimenez-Nacher I; Soriano V;
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正文语种 eng
中图分类传染病;
关键词
tipranavir; Carbon ion; Minute of time; Plasma; HIV; 血浆;

机译：tipranavir;Carbon ion;Minute of time;Plasma;HIV;血浆;

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1. Association between tipranavir plasma levels and virological response in HIV-infected patients. [J] . Morello J, Gasco PG, Rodriguez-Novoa S, AIDS Research and Human Retroviruses . 2008,第3期

机译：HIV感染患者的地普那韦血浆水平与病毒学应答之间的关联。
2. Short Communication: Association between Tipranavir Plasma Levels and Virological Response in HIV-Infected Patients [J] . Judit Morello Pilar Garcia Gascó Sonia Rodriguez-Novoa Carmen de Mendoza Francisco Blanco Gema Gonzalez-Pardo Beatriz Sanz Inmaculada Jimenez-Nacher Vincent Soriano AIDS Research and Human Retroviruses . 2008,第3期

机译：简短交流：HIV感染患者的Tipranavir血浆水平与病毒学应答之间的关联
3. Lack of association between plasma levels of non-nucleoside reverse transcriptase inhibitors & virological outcomes during rifampicin co-administration in HIV-infected TB patients. [J] . Geetha Ramachandran, A K Hemanth Kumar, C Ponnuraja, The Indian journal of medical research. . 2013,第6期

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4. Association of systemic cytokine levels with the local inflammatory response after implantation of plasma-modified titanium plates in rats [C] . L. Wilhelm, U. Walschus, A. Hoene, 23rd European conference on biomaterials 2010 . 2010

机译：血浆修饰的钛板植入大鼠后全身细胞因子水平与局部炎症反应的关系
5. Correlates of neuropsychological functioning and associations with therapeutic alliance in HIV-infected and HIV-uninfected opiate-dependent patients. [D] . Applebaum, Allison J. 2011

机译：HIV感染和未感染HIV的阿片依赖患者的神经心理学功能和与治疗联盟的关联。
6. Lack of association between plasma levels of non-nucleoside reverse transcriptase inhibitors virological outcomes during rifampicin co-administration in HIV-infected TB patients [O] . Geetha Ramachandran, A.K. Hemanth Kumar, C. Ponnuraja, 2013

机译：艾滋病毒感染的结核病患者联合使用利福平期间非核苷类逆转录酶抑制剂的血浆水平与病毒学结果之间缺乏关联
7. HIV DNA loads, plasma residual viraemia and risk of virological rebound in heavily treated, virologically suppressed HIV-infected patients. [O] . Gianotti, N., Canducci, F., Galli, L., 2015

机译：HIV DNa负荷，血浆残留病毒血症以及严重治疗，病毒学抑制的HIV感染患者的病毒学反弹风险。

Association between tipranavir plasma levels and virological response in HIV-infected patients.

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