Low Serum Trough Concentrations and High Vancomycin Minimum Inhibitory Concentration in Methicillin-Sensitive Staphylococcus aureus From Hemodialysis Patients in Brazil

da Vitoria Michel Penedo; de Sousa Alvarenga Cristiane Gomes; Vasconcellos Filho Lauro Monteiro; Teixeira Birro Jessica de Cassia; Barbosa Maralisi Coutinho; Ferreira Mariana Abou Mourad; Schuenck Ricardo Pinto; Ferreira Nunes Ana Paula; dos Santos Kenia Valeria

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Low Serum Trough Concentrations and High Vancomycin Minimum Inhibitory Concentration in Methicillin-Sensitive Staphylococcus aureus From Hemodialysis Patients in Brazil

机译：巴西血液透析患者的低血清槽浓度和高万霉素最小抑制素甲氧西林敏感葡萄球菌中的抑制浓度

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Background: The empiric antimicrobial therapy for bacteremia of long-term hemodialysis (HD) outpatients is currently based on the combination of vancomycin and gentamicin because of the high frequency of isolated Staphylococcus species. The vancomycin trough level range from 15 to 20 mcg/mL is expected for therapeutic success against methicillin-resistant Staphylococcus aureus with vancomycin minimum inhibitory concentration (MIC) >= 1.0 mcg/mL. Despite the availability of clinical practice guidelines for vancomycin therapeutic drug monitoring, these target serum concentrations are not reached in many patients.

机译：背景：长期血液透析（HD）门诊患者的肌菌抗菌治疗目前是基于万古霉素和庆大霉素的组合，因为分离的葡萄球菌物种的高频率。预期15至20mcg / ml的万古霉素槽水平范围为抗甲氧西林抗性金黄色葡萄球菌的治疗成功，具有万古霉素最小抑制浓度（MIC）> = 1.0mcg / ml。尽管有临床实践指南的万古霉素治疗药物监测，但许多患者未达到这些靶标血清浓度。

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来源
《Therapeutic Drug Monitoring》 |2019年第1期|共6页
作者
da Vitoria Michel Penedo; de Sousa Alvarenga Cristiane Gomes; Vasconcellos Filho Lauro Monteiro; Teixeira Birro Jessica de Cassia; Barbosa Maralisi Coutinho; Ferreira Mariana Abou Mourad; Schuenck Ricardo Pinto; Ferreira Nunes Ana Paula; dos Santos Kenia Valeria;
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作者单位

Fed Univ Espirito Santo UFES Hlth Sci Ctr Dept Pathol Marechal Campos Ave 1468 BR-29040090;

Clin Capixaba Rim Vitoria ES Brazil;

Clin Capixaba Rim Vitoria ES Brazil;

Fed Univ Espirito Santo UFES Hlth Sci Ctr Dept Pathol Marechal Campos Ave 1468 BR-29040090;

Fed Univ Espirito Santo UFES Hlth Sci Ctr Dept Pathol Marechal Campos Ave 1468 BR-29040090;

Fed Univ Espirito Santo UFES Hlth Sci Ctr Dept Pathol Marechal Campos Ave 1468 BR-29040090;

Fed Univ Espirito Santo UFES Hlth Sci Ctr Dept Pathol Marechal Campos Ave 1468 BR-29040090;

Fed Univ Espirito Santo UFES Hlth Sci Ctr Dept Pathol Marechal Campos Ave 1468 BR-29040090;

Fed Univ Espirito Santo UFES Hlth Sci Ctr Dept Pathol Marechal Campos Ave 1468 BR-29040090;

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原文格式 PDF
正文语种 eng
中图分类生药学（天然药物学）;
关键词
hemodialysis; Staphylococcus aureus; bacteremia; vancomycin trough concentration; vancomycin MIC;

机译：血液透析;金黄色葡萄球菌;菌血症;万古霉素槽浓度;万古霉素麦克风;

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1. Low Serum Trough Concentrations and High Vancomycin Minimum Inhibitory Concentration in Methicillin-Sensitive Staphylococcus aureus From Hemodialysis Patients in Brazil [J] . da Vitoria Michel Penedo, de Sousa Alvarenga Cristiane Gomes, Vasconcellos Filho Lauro Monteiro, Therapeutic Drug Monitoring . 2019,第1期

机译：巴西血液透析患者的低血清槽浓度和高万霉素最小抑制素甲氧西林敏感葡萄球菌中的抑制浓度
2. High vancomycin minimum inhibitory concentrations with heteroresistant vancomycin-intermediate Staphylococcus aureus in meticillin-resistant S. aureus bacteraemia patients [J] . Wang J.-L., Lai C.-H., Lin H.-H., International journal of antimicrobial agents . 2013,第5期

机译：对耐甲氧西林的金黄色葡萄球菌菌血症患者的耐万古霉素中间体金黄色葡萄球菌的高万古霉素最低抑菌浓度
3. The Impact of Serum Vancomycin Levels and Minimum Inhibitory Concentrations of Methicillin-Resistant Staphylococcus aureus on Mortality in Patients with Nosocomial Pneumonia [J] . Denise Pires Machado Luciano Z Goldani Rodrigo Minuto Paiva Valério Rodrigues Aquino Fernanda de-Paris Thiago Lisboa Bruno Jung, Rodrigo Pires dos Santos Canadian Journal of Infectious Diseases and Medical Microbiology: Journal Canadien des Maladies Infectieuses . 2013,第1期

机译：院内肺炎患者血清万古霉素水平和耐甲氧西林金黄色葡萄球菌最低抑菌浓度对死亡率的影响
4. INFLUENCE OF STAPHYLOCOCCUS AUREUS INTRAMAMMARY INFECTION ON SERUM COPPER, ZINC, AND IRON CONCENTRATIONS [C] . C.D. Luby, L. Viera, J.R. Middleton, Annual Meeting of the National Mastitis Council . 2003

机译：金黄色葡萄球菌嵌入血清铜，锌和铁浓度的影响
5. Zinc supplementation of maintenance hemodialysis patients: Effect on serum lipid and copper concentrations [D] . Chevalier, Celia Ann. 1990

机译：维持性血液透析患者补充锌：对血脂和铜浓度的影响
6. The ratio of pre-dialysis vancomycin trough serum concentration to minimum inhibitory concentration is associated with treatment outcomes in methicillin-resistant Staphylococcus aureus bacteremia [O] . Chien-Fang Fu, Jiun-Da Huang, Jann-Tay Wang, -1

机译：透析前万古霉素谷浓度与最低抑菌浓度之比与耐甲氧西林金黄色葡萄球菌菌血症的治疗效果相关
7. The ratio of pre-dialysis vancomycin trough serum concentration to minimum inhibitory concentration is associated with treatment outcomes in methicillin-resistant Staphylococcus aureus bacteremia [O] . Chien-Fang Fu, Jiun-Da Huang, Jann-Tay Wang, 2018

机译：透析前的透析性万古霉素血清浓度与最小抑制浓度的比率与甲氧西林抗金黄色葡萄球菌菌血症的治疗结果有关

Low Serum Trough Concentrations and High Vancomycin Minimum Inhibitory Concentration in Methicillin-Sensitive Staphylococcus aureus From Hemodialysis Patients in Brazil

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