Chinese Patients With Heart Valve Replacement Do Not Benefit From Warfarin Pharmacogenetic Testing on Anticoagulation Outcomes

Hao Yexia; Yang Jun; Zheng Xuan; Hu Yuanping; Yan Xinsheng; Zhang Litao

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Chinese Patients With Heart Valve Replacement Do Not Benefit From Warfarin Pharmacogenetic Testing on Anticoagulation Outcomes

机译：中国心脏瓣膜置换患者不会受益于抗凝成果的华法林药物发生测试

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Background: Genotype-guided warfarin dosing has been shown in some randomized trials to improve anticoagulation outcomes in individuals of European ancestry; yet, its utility in Chinese patients with heart valve replacement remains unresolved.

机译：背景：在一些随机试验中显示了基因型引导的Warfarin给药，以改善欧洲血统个人的抗凝结果; 然而，它在中国心脏瓣膜更换患者中的效用仍未解决。

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来源
《Therapeutic Drug Monitoring》 |2019年第6期|共7页
作者
Hao Yexia; Yang Jun; Zheng Xuan; Hu Yuanping; Yan Xinsheng; Zhang Litao;
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作者单位

Wuhan Univ Wuhan Asia Heart Hosp Dept Clin Lab Wuhan Peoples R China;

Wuhan Univ Wuhan Asia Heart Hosp Dept Clin Lab Wuhan Peoples R China;

Wuhan Univ Wuhan Asia Heart Hosp Lab Mol Cardiol Wuhan Peoples R China;

Wuhan Univ Wuhan Asia Heart Hosp Lab Mol Cardiol Wuhan Peoples R China;

Wuhan Univ Wuhan Asia Heart Hosp Dept Clin Lab Wuhan Peoples R China;

Wuhan Univ Wuhan Asia Heart Hosp Dept Clin Lab Wuhan Peoples R China;

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原文格式 PDF
正文语种 eng
中图分类生药学（天然药物学）;
关键词
warfarin; pharmacogenetic; CYP2C9; VKORC1; major bleeding; thrombotic;

机译：Warfarin;药物生成;CYP2C9;VKORC1;主要出血;血栓形成;

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专利

1. Chinese Patients With Heart Valve Replacement Do Not Benefit From Warfarin Pharmacogenetic Testing on Anticoagulation Outcomes [J] . Hao Yexia, Yang Jun, Zheng Xuan, Therapeutic Drug Monitoring . 2019,第6期

机译：中国心脏瓣膜置换患者不会受益于抗凝成果的华法林药物发生测试
2. Use of artificial neural network to predict warfarin individualized dosage regime in Chinese patients receiving low-intensity anticoagulation after heart valve replacement [J] . ZhouQ., KwongJ., ChenJ., International Journal of Cardiology . 2014,第3期

机译：使用人工神经网络预测中国患者心脏瓣膜置换术后接受低强度抗凝治疗的华法林个体化剂量方案
3. Comparison of the Performance of the Warfarin Pharmacogenetics Algorithms in Patients with Surgery of Heart Valve Replacement and Heart Valvuloplasty [J] . Xu Hang, Su Shi, Tang Wuji, Thrombosis Research: An International Journal on Vascular Obstruction, Hemorrhage and Hemostasis . 2015,第3期

机译：华法林药物遗传学算法在心脏瓣膜置换和心脏瓣膜成形手术中的性能比较
4. Pregnancy Outcomes in Women with Mechanical Heart Valves Receiving Anticoagulation [C] . Samiei N., Pouralizadeh S., Mirmesdagh Y., International Congress on Cardiac Problems in Pregnancy . 2012

机译：接受抗凝机的机械心脏瓣膜的孕妇的妊娠结局
5. Novel cardiovascular anticoagulation for thromboprophylaxis of mechanical heart valves in a porcine model of heterotopic valve replacement. [D] . Greiten, Lawrence Edward. 2016

机译：在异位瓣膜置换的猪模型中，新型心血管抗凝剂可预防机械性心脏瓣膜的血栓形成。
6. Verification of Pharmacogenetics-Based Warfarin Dosing Algorithms in Han-Chinese Patients Undertaking Mechanic Heart Valve Replacement [O] . Li Zhao, Chunxia Chen, Bei Li, -1

机译：基于药理学的华法林剂量算法在汉族接受机械性心脏瓣膜置换术的患者中的应用
7. Verification of pharmacogenetics-based warfarin dosing algorithms in Han-Chinese patients undertaking mechanic heart valve replacement. [O] . Li Zhao, Chunxia Chen, Bei Li, 2014

机译：验证基于药物遗传学的华法林给药算法在汉族患者进行机械心脏瓣膜置换术。

Chinese Patients With Heart Valve Replacement Do Not Benefit From Warfarin Pharmacogenetic Testing on Anticoagulation Outcomes

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