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首页> 外文期刊>AIDS patient care and STDs >Postpartum discontinuation of antiretroviral therapy and risk of maternal AIDS-defining events, non-AIDS-defining events, and mortality among a cohort of HIV-1-infected women in the United States.
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Postpartum discontinuation of antiretroviral therapy and risk of maternal AIDS-defining events, non-AIDS-defining events, and mortality among a cohort of HIV-1-infected women in the United States.

机译：美国一群受HIV-1感染的女性在产后中止抗逆转录病毒疗法以及定义孕妇AIDS，非AIDS事件和死亡率的风险。

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This retrospective cohort study of HIV-infected women receiving highly active antiretroviral therapy (HAART) while pregnant assessed the effect of postpartum HAART discontinuation on maternal AIDS-defining events (ADEs), non-AIDS-defining events (non-ADEs), and death 1997-2008 in Nashville, Tennessee. Cox proportional hazards models compared rates of ADE or all-cause death and non-ADE or all-cause death, and competing risks analyses compared rates of ADE or ADE-related death and non-ADE or non-ADE-related death across the groups. There were two groups: women who stopped HAART postpartum (discontinuation, n = 54) and women who continued HAART postpartum (continuation, n = 69). Fifty percent were African American, 40% had prior non-HAART antiretroviral therapy (ART) use, and 38% had a history of illicit drug use. Median age was 27.5 years, baseline CD4(%) was 532 (34%) and CD4 nadir was 332 cells/mm(3), baseline and peak HIV-1 RNA were 2.6 and 4.32 log(10) copies per milliliter, respectively. Women in the continuation group were older, had lower baseline CD4, CD4%, and CD4 nadir, and had higher peak HIV-1 RNA. In multivariable proportional hazards models, the hazard ratios [95% confidence interval (CI)] of ADE or all-cause death and non-ADE or all-cause death were lower in the continuation group, but not statistically significantly: 0.50 (0.12, 2.12; p = 0.35) and 0.69 (0.24, 1.95; p = 0.48), respectively. The results were similar in competing risks analyses. Despite having characteristics associated with worse prognosis, women who continued HAART postpartum had lower hazard ratio point estimates for ADEs or death and non-ADEs or death than women who discontinued HAART. Larger studies with longer follow-up are indicated to assess this association.
机译：这项回顾性队列研究对怀孕期间接受高活性抗逆转录病毒疗法（HAART）的HIV感染妇女进行了评估，评估了产后HAART停药对母体AIDS定义事件（ADEs），非AIDS定义事件（non-ADEs）和死亡的影响。 1997-2008年在田纳西州纳什维尔市。 Cox比例风险模型比较了ADE或全因死亡和非ADE或全因死亡的比率，竞争风险分析则比较了各组中ADE或ADE相关死亡以及非ADE或非ADE相关死亡的比率。分为两组：停产后停止HAART的妇女（停药，n = 54）和停产后继续HAART的妇女（停药，n = 69）。 50％是非裔美国人，40％曾经使用过非HAART抗逆转录病毒疗法（ART），38％曾经有非法药物使用史。中位年龄为27.5岁，基线CD4（％）为532（34％），最低CD4为332细胞/ mm（3），基线和最高HIV-1 RNA分别为每毫升2.6和4.32 log（10）拷贝。延续组的妇女年龄较大，基线CD4，CD4％和CD4最低点较低，并且HIV-1 RNA峰值较高。在多变量比例风险模型中，延续组的ADE或全因死亡和非ADE或全因死亡的危险比[95％置信区间（CI）]较低，但无统计学意义：0.50（0.12， 2.12; p = 0.35）和0.69（0.24，1.95; p = 0.48）。在竞争风险分析中，结果相似。尽管具有预后较差的特征，但继续进行HAART产后的妇女与停用HAART的妇女相比，ADEs或死亡和非ADEs或死亡的危险比估计值较低。较大的随访时间较长的研究表明可以评估这种关联。

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