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首页> 外文期刊>AIDS Research and Human Retroviruses >Short Communication: Effects of Omega-3 Fatty Acids on Triglycerides and High-Density Lipoprotein Subprofiles in HIV-lnfected Persons with Hypertriglyceridemia
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Short Communication: Effects of Omega-3 Fatty Acids on Triglycerides and High-Density Lipoprotein Subprofiles in HIV-lnfected Persons with Hypertriglyceridemia

机译：简短交流：Omega-3脂肪酸对HIV感染的高甘油三酯血症人群的甘油三酸酯和高密度脂蛋白亚谱的影响

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摘要

Hypertriglyceridemia and low high-density lipoprotein (HDL)-cholesterol (HDL-C) may contribute to a presumed accelerated risk for cardiovascular disease in HIV-infected individuals. We evaluated the effect of omega-3 fatty acid treatment on triglycerides, low-density lipoprotein (LDL)-C, HDL-C, and HDL subpopulations. Forty-one HTV-seropositive subjects with hypertriglyceridemia (> 150 mg/dl) on active antiretroviral therapy were enrolled in this placebo-controlled, double-blind, randomized, crossover trial comparing the effects of omega-3 fatty acid treatment (1.9 g EPA and 1.5 g DHA) on triglycerides, LDL-C, HDL-C, and HDL subpopulations. An independent sample t-test was used to assess the study start to posttreatment change for all components. After omega-3 fatty acid treatment, triglyceride levels decreased 63.2± 86.9 mg/dl (p< 0.001). No significant changes in total cholesterol, LDL-C, or HDL-C were found. Within HDL subpopulations, significant changes were seen in the most ather-oprotective HDL particles, alpha-1, which increased by 2.5±5.6mg/dl (p<0.05), and prea-1, which increased by 0.6 ±1.0 mg/dl (p< 0.001). Prea-3, a presumably atherogenic HDL particle, decreased by 0.5 ± 0.9 mg/dl (p < 0.01). Omega-3 fatty acid treatment significantly lowered triglyceride levels in HIV-positive patients with moderate hypertriglyceridemia. While no study-wide improvements in LDL-C or HDL-C were detected, the HDL subpop-ulation profile changed in a beneficial way suggesting more cardioprotection after treatment.
机译：高甘油三酸酯血症和低密度脂蛋白（HDL）-胆固醇（HDL-C）可能会导致HIV感染者的心血管疾病风险加快。我们评估了omega-3脂肪酸治疗对甘油三酸酯，低密度脂蛋白（LDL）-C，HDL-C和HDL亚群的影响。这项安慰剂对照，双盲，随机，交叉试验纳入了41名接受高甘油三酯血症（> 150 mg / dl）主动抗逆转录病毒治疗的HTV血清阳性受试者，比较了omega-3脂肪酸治疗（1.9 g EPA）的效果以及在甘油三酸酯，LDL-C，HDL-C和HDL亚群上添加1.5 g DHA）。使用独立的样本t检验来评估研究开始到所有成分的后处理变化。 omega-3脂肪酸处理后，甘油三酸酯水平降低了63.2±86.9 mg / dl（p <0.001）。未发现总胆固醇，LDL-C或HDL-C的显着变化。在高密度脂蛋白亚群中，对大多数抗动脉粥样硬化的高密度脂蛋白颗粒α-1的变化显着，增加了2.5±5.6mg / dl（p <0.05），而prea-1的颗粒增加了0.6±1.0 mg / dl （p ＜0.001）。 Prea-3（可能是致动脉粥样硬化的HDL颗粒）降低了0.5±0.9 mg / dl（p <0.01）。 Omega-3脂肪酸治疗可显着降低中度高甘油三酯血症的HIV阳性患者的甘油三酸酯水平。虽然未检测到LDL-C或HDL-C的研究范围内的改善，但HDL亚群的分布以有益的方式改变，提示治疗后有更多的心脏保护作用。

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