Short Communication: Phylogenetic and Molecular Characterization of Six Full-Length HIV-1 Genomes from India Reveals a Monophyletic Lineage of Indian Sub-Subtype A1

Pandey Sudhanshu Shekhar; Cherian Sarah; Thakar Madhuri; Paranjape Ramesh S.

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Short Communication: Phylogenetic and Molecular Characterization of Six Full-Length HIV-1 Genomes from India Reveals a Monophyletic Lineage of Indian Sub-Subtype A1

机译：简短交流：来自印度的六个完整的HIV-1基因组的系统发育和分子表征揭示了印度A1亚型的单系谱系。

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Although HIV-1 epidemic in India is mainly driven by subtype C, subtype A has been reported for over two decades. This is the first comprehensive analysis of sequences of HIV-1 subtype A from India, based on the near full-length genome sequences of six different HIV-1 subtype A Indian isolates along with available partial gene sequences from India and global sequences. The phylogenetic analyses revealed the convergence of all Indian whole-genome sequences and majority of the partial gene sequences to a single node with the sequences most closely related to African sub-subtype A1. The presence of the signature motifs consistent with those observed in subtype A and CTL epitopes characterized specifically for subtype A1 were observed among the study sequences. Deletion of LY amino acid of LYPXnL motif of p6gag and one amino acid in V3 loop have been observed among the study isolates, which have also been observed in a few sequences from East Africa. Overall, the results are indicative of a monophyletic lineage or founder effect of the Indian epidemic due to sub-subtype A1 and supportive of a possible migration of subtype A1 into India from East Africa.

机译：尽管印度的HIV-1流行主要是由C型亚型引起的，但已有20多年的时间报道了A型亚型。这是对来自印度的HIV-1亚型A序列的首次全面分析，基于六个不同的HIV-1亚型A印度分离株的近乎全长基因组序列，以及来自印度的可用部分基因序列和全球序列。系统发育分析表明，所有印度全基因组序列和大部分部分基因序列都收敛到单个节点，该序列与非洲亚型A1最密切相关。在研究序列中观察到签名基序的存在与在亚型A和CTL表位中观察到的特征性基序一致，这些特征专门针对亚型A1。在研究分离物中已观察到p6gag的LYPXnL基序的LY氨基酸的缺失和V3环中的一个氨基酸的缺失，在东非的一些序列中也观察到。总体而言，这些结果表明，由于A1亚型引起了印度流行病的单系谱系或始祖效应，并支持了A1亚型可能从东非迁移到印度。

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《AIDS Research and Human Retroviruses》 |2016年第5期|共14页
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Pandey Sudhanshu Shekhar; Cherian Sarah; Thakar Madhuri; Paranjape Ramesh S.;
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1. Short Communication: Phylogenetic and Molecular Characterization of Six Full-Length HIV-1 Genomes from India Reveals a Monophyletic Lineage of Indian Sub-Subtype A1 [J] . Pandey Sudhanshu Shekhar, Cherian Sarah, Thakar Madhuri, AIDS Research and Human Retroviruses . 2016,第5期

机译：简短交流：来自印度的六个完整的HIV-1基因组的系统发育和分子表征揭示了印度A1亚型的单系谱系。
2. Phylogenetic Analysis of Ethiopian HIV-1 Subtype C Near Full-Length Genomes Reveals High Intrasubtype Diversity and a Strong Geographical Cluster [J] . Amogne Wondwossen, Bontell Irene, Grossmann Sebastian, AIDS Research and Human Retroviruses . 2016,第5期

机译：全长基因组附近的埃塞俄比亚HIV-1 C亚型的系统发育分析揭示了高度的亚型内多样性和强大的地理簇
3. Full-length genome sequence of a simian immunodeficiency virus from a wild-captured sun-tailed monkey in Gabon provides evidence for a species-specific monophyletic SIVsun lineage. [J] . Liegeois F, Butel C, Mouinga Ondeme A, AIDS Research and Human Retroviruses . 2011,第11期

机译：来自加蓬野生捕获的太阳尾猴的猿猴免疫缺陷病毒的全长基因组序列，为物种特异性单系SIVsun谱系提供了证据。
4. MOLECULAR CHARACTERIZATION OF SUGARCANE GRASSY SHOOT PHYTOPLASMA INFECTING SUGARCANE IN INDIA AND ITS PHYLOGENETIC RELATIONSHIPS TO CLOSELY RELATED PHYTOPLASMAS [C] . G.P. Rao, R.R. Singh, S.B. Singh Sugar Technologists' Association of India Annual Convention; 20070822-24; Goa(IN) . 2007

机译：影响印度甘蔗的甘蔗草茎植物的分子特征及其与紧密相关植物的系统发育关系
5. PREMCHAND'S IMAGE OF INDIAN WOMANHOOD AS REVEALED IN HIS SHORT STORIES. [D] . ORR, INGE C. 1963

机译：在他的短篇小说中揭示了PREMCHAND的印度女性形象。
6. Phylogenetic Characterization of Six Full-Length HIV-1 Subtype C Molecular Clones from Three Patients: Identification of Rare Subtype C Strains Containing Two NF-κB Motifs in the Long Terminal Repeat [O] . Luke Elizabeth Hanna, Ujjwal Neogi, Udaykumar Ranga, -1

机译：来自三名患者的六个全长HIV-1 C型亚克隆分子的系统发生特征：鉴定的长末端重复序列中含有两个NF-κB母模的罕见C型亚株。
7. Highly complex neutralization determinants on a monophyletic lineage of newly transmitted subtype C HIV-1 Env clones from India [O] . Kulkarni Smita S., Lapedes Alan, Tang Haili, 2009

机译：来自印度新传播的C型HIV-1 Env克隆单系谱系的高度复杂的中和决定簇

Short Communication: Phylogenetic and Molecular Characterization of Six Full-Length HIV-1 Genomes from India Reveals a Monophyletic Lineage of Indian Sub-Subtype A1

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