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首页> 外文期刊>AIDS Research and Human Retroviruses >Short communication: evidence of HIV type 1 complex and second generation recombinant strains among patients infected in 1997-2007 in France: ANRS CO06 PRIMO Cohort.
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Short communication: evidence of HIV type 1 complex and second generation recombinant strains among patients infected in 1997-2007 in France: ANRS CO06 PRIMO Cohort.

机译：简短交流：1997年至2007年法国感染的患者中HIV 1型复合物和第二代重组菌株的证据：ANRS CO06 PRIMO队列。

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Although subtype B strains are still predominant in France, non-B viruses have been isolated from 26% of patients with a primary HIV-1 infection in 2005-2006. The objective of this study was to characterize recombinant-HIV-1 strains by a subtyping based on the phylogenetic analysis of both pol and env sequences. We studied 591 patients who were part of the French PRIMO-Cohort between 1997 and 2007. The RT and V3 regions were sequenced and phylogenetic analyses were performed. Phylogenetic analyses showed concordant subtype results for 91.7% of viruses: 71.6% of the viruses were subtype B and 28.4% belonged to non-B subtypes or circulating recombinant forms (CRFs). Forty-nine strains showed different phylogenies between the two genes (pol and env), indicating that recombinations were observed in 8.3% of the cases. These recombinants were observed in patients from sub-Saharan Africa (28.3%) and in white patients (6.3%). Moreover, among the 49 recombinant viruses, 15 (30.6%) contained a B sequence in the pol or in the env gene compared to 34 (69.4%), which contained non-B or CRF sequences. Twenty-six different recombination patterns involving subtypes, CRFs, or undetermined strains were observed. We have reported the occurrence of new recombinant forms between the two major viral types of strains circulating in France: subtype B and CRF02_AG. Our study confirms a high HIV-1 diversity among patients infected in France within the past 10 years, with a high proportion of non-B strains and the circulation of complex recombinant strains among both sub-Saharan patients and French patients.
机译：尽管在法国B型亚型病毒仍占主导地位，但在2005年至2006年间，已从26％的原发性HIV-1感染患者中分离出非B型病毒。这项研究的目的是基于pol和env序列的系统发育分析，通过亚型鉴定重组HIV-1菌株。我们研究了1997年至2007年间属于法国PRIMO队列的591例患者。对RT和V3区域进行了测序，并进行了系统发育分析。系统发育分析显示91.7％的病毒具有相同的亚型结果：71.6％的病毒属于B亚型，而28.4％属于非B亚型或循环重组形式（CRF）。 49个菌株在两个基因（pol和env）之间显示出不同的系统发育，表明在8.3％的病例中观察到重组。在来自撒哈拉以南非洲地区的患者（28.3％）和白人患者（6.3％）中观察到了这些重组体。此外，在49种重组病毒中，有15种（30.6％）在pol或env基因中包含B序列，而34种（69.4％）包含非B或CRF序列。观察到26种不同的重组模式，涉及亚型，CRF或不确定的菌株。我们已经报道了在法国传播的两种主要病毒类型之间发生了新的重组形式：亚型B和CRF02_AG。我们的研究证实，在过去的10年中，法国感染的患者中HIV-1的多样性很高，非B株的比例很高，并且复杂的重组株在撒哈拉以南的撒哈拉以南患者和法国的患者中均有传播。

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