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首页> 外文期刊>AIDS Research and Human Retroviruses >Short Communication: Preferential Concentration of Hydroxychloroquine in Adenoid Tissue of HIV-lnfected Subjects
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Short Communication: Preferential Concentration of Hydroxychloroquine in Adenoid Tissue of HIV-lnfected Subjects

机译：简短交流：艾滋病毒感染者腺样组织中羟氯喹的优选浓度

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Hydroxychloroquine (HCQ) anti-HIV activity is well documented. To evaluate its distribution in lymphoid tissues, which are considered sanctuaries of HIV reservoirs and targets of early massive depletion of CD4~+ T cells, we assessed HCQ concentrations in adenoid tissue and plasma of HIV-infected subjects. A daily oral dose of 400 or 800 mg of HCQ was administered to eight HIV-infected subjects for 8 days. HCQ concentrations were measured in plasma and adenoid tissue by high-performance liquid chromatography. Mean concentrations of HCQ in adenoid tissue of subjects treated with 400 and 800 mg were 87,210 +- 17,817 and 167,472 +- 93,793 ng/g, respectively. In plasma, these values corresponded to 329 +- 133 and 278 +- 68 ng/g, respectively. HCQ concentrations were significantly higher in adenoid tissue than in plasma in both groups. The potential use of HCQ as adjuvant in the therapy of HIV deserves to be explored, as the drug accumulates in relevant tissues for HIV replication and immunopathogenesis.
机译：羟氯喹（HCQ）的抗HIV活性已得到充分证明。为了评估其在淋巴样组织中的分布，淋巴组织被认为是HIV贮藏所和早期大量消耗CD4 ++ T细胞的靶标，我们评估了HIV感染者的腺样体组织和血浆中的HCQ浓度。每天向八名受HIV感染的受试者口服400或800毫克HCQ的口服剂量，持续8天。通过高效液相色谱法测定血浆和腺样体组织中的HCQ浓度。在接受400和800 mg治疗的受试者的腺样体组织中，HCQ的平均浓度分别为87,210±17,817和167,472±93,793 ng / g。在血浆中，这些值分别对应于329±133和278±68ng / g。两组中腺样体组织中的HCQ浓度均显着高于血浆中。 HCQ作为HIV佐剂的潜在用途值得探讨，因为该药物在HIV的复制和免疫发病机理的相关组织中积累。

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