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首页> 外文期刊>Therapeutic apheresis and dialysis: official peer-reviewed journal of the International Society for Apheresis, the Japanese Society for Apheresis, the Japanese Society for Dialysis Therapy >Super High‐Flux Continuous Venovenous Hemodialysis Using Regional Citrate Anticoagulation: Long‐Term Stability of Middle Molecule Clearance
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Super High‐Flux Continuous Venovenous Hemodialysis Using Regional Citrate Anticoagulation: Long‐Term Stability of Middle Molecule Clearance

机译：超高通量连续血型血液透析使用氨柠檬酸盐抗凝：中分子间隙的长期稳定性

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摘要

Abstract Continuous renal replacement therapy is a standard treatment in critically ill patients with acute kidney injury. All CRRT techniques provide a high low‐molecular weight clearance but even with hemofiltration, clearance of middle molecules is low. We investigated whether a new super high‐flux hemofilter provides effective and sustained middle molecule clearance during citrate‐anticoagulated continuous venovenous hemodialysis for up to 72?h. We included 14 critically ill patients with AKI‐KDIGO‐III in a prospective observational trial. We measured/calculated blood and urine concentrations, clearances and sieving coefficients of eight molecules with molecular weights from 60 to 66?kDa, hemodynamic parameters and SAPS‐II scores. All filters were patent at 72?h. Clearance and sieving coefficients of small solutes were high and sustained over time, those for larger solutes decreased over 72?h but remained high enough to decrease blood concentrations of solutes up to 25?kDa. Albumin serum levels remained unaffected. Catecholamine doses and SAPS‐II scores decreased significantly. This new hemofilter may improve blood purification in critically ill patients with AKI.
机译：摘要连续肾置换疗法是急性肾损伤患者的标准治疗。所有CRRT技术都提供了高分子量的间隙，但即使用血液过滤，中间分子的间隙也很低。我们调查了一种新的超高通量血液过滤器是否在柠檬酸盐 - 抗凝的连续血管血液透析中提供了有效和持续的中分子间隙，最高可达72μl。在预期的观察试验中，我们包含14名患有Aki-Kdigo-III的患者。我们测量/计算出血液和尿液浓度，间隙和筛分系数，其中八个分子的分子量为60至66ΩkDa，血液动力学参数和SAPS-II分数。所有过滤器都是72℃的专利。小溶质的间隙和筛分系数随着时间的推移高且持续，较大溶质的溶质超过72μl，但保持足够高，以降低血液浓度高达25μkKDA。白蛋白血清水平不受影响。儿茶酚胺剂量和SAPS-II分数显着下降。这种新的血液过滤器可能会改善患有症患者的血液净化。

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