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Ibuprofen intercalation and release from different layered double hydroxides

机译：来自不同层次的双氢氧化物的布洛芬嵌入和释放

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摘要

Aim: The chemical composition of layered double hydroxides (LDHs) affects their structure and properties. The method of ibuprofen (IBU) intercalation into LDHs may modify its release, reduce adverse effects and decrease the required dosing frequency. Methodology: This study investigates the effects of four different LDHs; MgAI-LDH, MgFe-LDH, NiAI-LDH and NiFe-LDH on in vitro release of IBU intercalated by coprecipi-tation and anionic-exchange. Results: MgAI-LDH was the most crystalline and substitution of either cation decreased LDH order. Fourier-transform infrared spectra and power x-ray diffractograms confirmed the intercalation of IBU within the lamellar structure of MgAI-LDH and MgFe-LDH. Intercalation of IBU by anion-exchange resulted in slower, partial, drug release compared with coprecipitation. Conclusion: The chemical composition of LDHs affects their crystallinity, IBU intercalation and subsequent release. ^g>anionic exchange; coprecipitation; drug release; ibuprofen; layered double hydroxides; LDH
机译：目的：层状双氢氧化物（LDHs）的化学成分影响它们的结构和性质。将布洛芬（IBU）插入到LDH中的方法可以改变其释放，减少不利影响并降低所需的计量频率。方法论：本研究调查了四种不同LDH的影响; Mgai-LDH，MGFE-LDH，NIAI-LDH和NIFE-LDH在IBU的体外释放中，IBU通过COPRecipi-Tation和阴离子交换插入。结果：Mgai-LDH是任一阳离子的结晶和替代性降低。傅立叶变换红外光谱和功率X射线衍射图证实了Mgai-LDH和MgFe-LDH的层状结构内的IBU的插入。与CopRecipitation相比，Anion-Exchange的IBU嵌入导致较慢，部分药物释放。结论：LDH的化学成分影响它们的结晶度，IBU嵌入和随后的释放。 ^ g>阴离子交换;共沉淀;药物释放;布洛芬;分层双氢氧化物; LDH.

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