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Nonlamellar liquid crystals: a new paradigm for the delivery of small molecules and bio-macromolecules

机译:非混凝土液晶:一种用于递送小分子和生物大分子的新范式

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The aim of this article is to collate the recent developments in the field of drug delivery, medical therapeutics and diagnostics specifically involving the nonlamellar liquid crystalline (NLC) systems. This review highlights different NLC phases having cubic, hexagonal and sponge internal structures, and their application in the field of drug delivery, such as dose reduction, toxicity reduction and therapeutic efficacy enhancement either in the form of nanoparticles, colloidal dispersion or gels. In addition, application of NLC systems as vehicles for peptides, proteins and as a theranostic system in cancer and other disease conditions is also elaborated, which is a growing platform of interest. Overall, the present review gives us a complete outlook on applications of NLC systems in the field of medicine.
机译:本文的目的是在特异性涉及非混凝土液晶(NLC)系统的药物递送,医学治疗和诊断领域的最新发展。 本综述突出了不同的NLC阶段具有立方体,六边形和海绵内部结构,以及它们在药物递送领域的应用,例如以纳米颗粒,胶体分散体或凝胶的形式进行剂量降低,毒性降低和治疗效能增强。 此外,还阐述了肽,蛋白质和作为癌症和其他疾病条件中作为肽和治疗系统的车辆的载体,这是一种日益增长的感兴趣平台。 总体而言,本综述为我们提供了全面的NLC系统在医学领域的应用展望。

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