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Application of simplex lattice design for the development of extended release tablets of model drug diclofenac sodium

机译：单纯胶片设计在模型药物二氯芬太尼钠延长释放片开发中的应用

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Aim: Simplex lattice design was applied to predict extent of drug release from extended release diclofenac sodium tablets. Methods: The effects of composition on dissolution rate were evaluated by varying the levels of hydroxypropyl methylcellulose, dicalcium phosphate and cornstarch via three component design. Results: The rate of drug release was primarily dictated by the proportion of hydroxypropyl methylcellulose and was also affected by the proportion of dicalcium phosphate and the method of processing (direct compression/wet granulation). Polynomial equations constructed for directly compressed and wet-granulated formulations could successfully predict the extent of drug release at an arbitrary time point of 3 h. Conclusion: Simplex lattice design is a viable tool to predict the drug release patterns of extended release formulations.
机译：目的：应用单纯晶格设计以预测延长释放双氯芬酸钠片的药物释放程度。 方法：通过三种组分设计改变羟丙基甲基纤维素，磷酸二钙和玉米淀粉的水平来评价组合物对溶出速率的影响。 结果：药物释放速率主要由羟丙基甲基纤维素的比例决定，也受磷酸二钙和加工方法（直接压缩/湿造粒）的影响。 用于直接压缩和湿造粒制剂构造的多项式方程可以成功预测3小时的任意时间点的药物释放程度。 结论：Simplex格子设计是一种可行的工具，可预测延长释放制剂的药物释放模式。

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