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Skin toxicity of topically applied nanoparticles

机译：局部施用纳米粒子的皮肤毒性

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摘要

Nowadays, nanoproducts have found numerous applications, allowing them to enter the human body in different ways. Skin is a major body organ that acts as the first-line barrier between the internal organs and external environment. Although the inhalation and ingestion of nanoparticles is more dangerous compared with skin exposure, there are noteworthy information gaps in skin exposure to nanoparticles that need much attention. Despite the few reviews in the literature on the cytotoxic effects of nanoparticles, no research has reviewed the clinical side effects of nanoparticles following topical admonition, including skin inflammation, skin cancer and genetic toxicity. Toxicology is a discipline overlapping with biology, chemistry and medicine, dealing with harmful effects of biological, chemical or physical mediators on living organisms. The innovation in chemicals and products cannot be fathomed without suitable and advanced toxicological studies. The importance of toxicity studies lies in setting up a dose-response curve and assuring the safety of new substances for use as pesticides, medicine or food stabilizers before they are recorded for common use in industry or medical clinics. In this regard, studying materials’ toxicology and performing standard toxicological experiments would allow for a better assessment of these materials and their effects.
机译：如今，纳费地发现了许多应用，允许它们以不同的方式进入人体。皮肤是一种主要的身体器官，充当内脏器官和外部环境之间的一线屏障。虽然与皮肤暴露相比，吸入和摄入纳米颗粒更危险，但皮肤暴露于需要很多关注的纳米颗粒中有值得注意的信息。尽管文献中的纳米粒子的细胞毒性效应几个评论，但局部警告后纳米颗粒的临床副作用尚未进行审查，包括皮肤炎症，皮肤癌和遗传毒性。毒理学是一种与生物学，化学和药物重叠的学科，处理生物，化学或物理介质对生物体的有害影响。无需适当和晚期毒理学研究，化学品和产品的创新就不能受到悲惨。毒性研究的重要性在于建立剂量 - 反应曲线，并确保在工业或医学诊所的常用常见之前使用作为农药，药物或食物稳定剂的新物质的安全性。在这方面，研究材料的毒理学和表演标准毒理学实验将允许更好地评估这些材料及其效果。

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