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Barbiturate derived amphiphilic homopolymers: synthesis, characterization, self-assembly and anticancer drug delivery

机译：巴比妥酸酯衍生的两亲均聚物：合成，表征，自组装和抗癌药物递送

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摘要

Aim: Our aim was to synthesis and characterization of amphiphilic norbornene-derived thiobarbiturate homopolymers (NDTH 1-4) for drug delivery. Methods: Ring-opening metathesis polymerization technique was used to prepare a series of homopolymers. The hydrophobicity is introduced by increasing the number of carbon chains ([-CH2-]n; n = 1, 2, 3 & 4) in between norbornene backbone and thiobarbiturate species. Results: These vesicular aggregates have been used as anticancer Doxorubicin drug delivery vehicles at the acidic (5.5) and physiological (7.4) pHs. Confocal laser-scanning microscopy has demonstrated that the drug-loaded vesicles are easily internalized into living cells. Conclusion: Amphiphilic norbornene-derived thiobarbiturate homopolymer assemblies showed efficient nanocarrier for effective anticancer drug delivery.
机译：目的：我们的目的是合成和表征两亲降冰片烯衍生的硫酸盐均聚物（NDTH 1-4）用于药物递送。 方法：采用开环复分解聚合技术制备一系列均聚物。 通过增加降冰片烯主链和硫酰氨基磺酸盐物种之间的碳链（[-CH2-] N = 1,4,3和4）的碳链（[-CH2-] N = 1,2,3和4）来引入疏水性。 结果：这些凹凸聚集体已被用作酸性（5.5）和生理（7.4）pHS的抗癌的多亮霉素药物递送载体。 共聚焦激光扫描显微镜证明了药物负载的囊泡容易内化为活细胞。 结论：两亲降冰片烯衍生的硫酰氨基磺酸盐均聚物组件显示出有效的抗癌药物递送的高效纳米载体。

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  • 来源
    《Therapeutic delivery》 |2019年第7期|共13页
  • 作者

    Shivshankar R Mane;

  • 作者单位

    Department of Chemical Sciences Polymer Research Centre Centre for Advance Functional Materials;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类 临床医学;
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