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首页> 外文期刊>Therapeutic delivery >Solid dispersion technology as a strategy to improve the bioavailability of poorly soluble drugs
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Solid dispersion technology as a strategy to improve the bioavailability of poorly soluble drugs

机译：稳定的分散技术作为提高可溶性药物差的生物利用度的策略

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摘要

Over the last half-century, solid dispersions (SDs) have been intensively investigated as a strategy to improve drugs solubility and dissolution rate, enhancing oral bioavailability. In this review, an overview of the state of the art of SDs technology is presented, focusing on their classification, the main preparation methods, the limitations associated with their instability, and the marketed products. To fully take advantage of SDs potential, an improvement in their physical stability and the ability to prolong the supersaturation of the drug in gastrointestinal fluids is required, as well as a better scientific understanding of scale-up for defining a robust manufacturing process. Taking these limitations into account will contribute to increase the number of marketed pharmaceutical products based on SD technology.
机译：在过去的半个世纪中，已经集中调查了固体分散体（SDS）作为改善药物溶解度和溶出速率的策略，增强口服生物利用度。 在本次审查中，提出了SDS技术领域的概述，专注于他们的分类，主要准备方法，与其不稳定相关的限制以及市场产品。 为了充分利用SDS潜力，需要改善其物理稳定性和延长药物在胃肠流体中的过饱和的能力，以及对定义稳健的制造过程的扩展方案的更好科学理解。 考虑这些限制将有助于增加基于SD技术的营销药品数量。

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