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首页> 外文期刊>AIDS Research and Human Retroviruses >Increased Steady-State Memory B Cell Subsets Among High-Risk Participants in an HIV Vaccine Trial
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Increased Steady-State Memory B Cell Subsets Among High-Risk Participants in an HIV Vaccine Trial

机译：HIV疫苗试验中高危参与者中稳态记忆B细胞亚群的增加

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The success of an HIV vaccine will require induction of a protective immune response in the most at-risk populations. The increased incidence of HIV infection in high-risk populations is assumed to be primarily the result of more frequent exposure to the virus or a greater inoculum of the virus; however, underlying variations in immune homeostasis may also contribute to HIV susceptibility and potentially impact vaccine responses and those required for protection. As an effective humoral immune response is likely to be a critical component of a protective HIV vaccine, we evaluated the steady-state phenotypic profile of peripheral blood B cells by flow cytometry from participants in the HIV Vaccine Trials Network (HVTN) 203 Phase 2a HIV vaccine trial considered to be at higher risk and lower risk for HIV acquisition. Overall, high-risk participants exhibited increased frequency of unswitched IgM memory and activated switched IgD(-)CD95(+) memory B cells than low-risk participants. Most (93%) of the high-risk male participants were men who have sex with men who engaged in high-risk sexual behavior. High-risk males had a significantly increased frequency of CXCR3(+) IgD(-)CD95(+) B cells than low-risk males. These results suggest that high-risk populations have altered B cell homeostasis. The increased frequency of activated and memory B cells may suggest increased immune activation in high-risk populations, which may contribute to possible differential responses to HIV vaccine strategies.
机译：HIV疫苗的成功需要在大多数高危人群中诱导保护性免疫应答。高风险人群中HIV感染的发生率增加，主要是由于更频繁地接触该病毒或该病毒接种量增加所致;但是，免疫稳态的潜在变化也可能导致HIV易感性，并可能影响疫苗反应和保护所需的反应。由于有效的体液免疫应答可能是保护性HIV疫苗的重要组成部分，因此我们通过流式细胞术评估了HIV疫苗试验网络（HVTN）203阶段2a HIV参与者的外周血B细胞的稳态表型概况疫苗试验被认为具有较高的感染风险，而感染艾滋病毒的风险较低。总体而言，高风险参与者比低风险参与者表现出更高的未切换IgM记忆和激活的切换IgD（-）CD95（+）记忆B细胞频率。高风险男性参与者中的大多数（93％）是与从事高风险性行为的男人发生性关系的男人。高风险男性比低风险男性的CXCR3（+）IgD（-）CD95（+）B细胞频率显着增加。这些结果表明高危人群已经改变了B细胞稳态。活化和记忆B细胞的频率增加可能表明高危人群中的免疫活化增加，这可能有助于对HIV疫苗策略的不同反应。

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