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首页> 外文期刊>AIDS Research and Human Retroviruses >HIV type 1 subtype C and CB Pol recombinants prevail at the cities with the highest AIDS prevalence rate in Brazil.
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HIV type 1 subtype C and CB Pol recombinants prevail at the cities with the highest AIDS prevalence rate in Brazil.

机译：在巴西，艾滋病患病率最高的城市普遍存在HIV 1型C型和CB型Pol重组病毒。

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HIV-1 B is predominant in Brazil, but HIV-1 C has increasingly been reported in the south of the country. However, many samples clustering with clade C are actually a recombinant, with a small B segment at RT (CRF31). Samples (209) from the three cities with the highest aids prevalence rate are analyzed. Partial polymerase sequences from HIV RNA made it possible to determine HIV clades and recombination patterns and to identify primary drug resistance mutations (DRMs). The incidence was estimated with a BED assay. HIV-1 C and CRF31 patterns were twice as frequent as clade B at all sites, but the proportion of C and CRF31 patterns was significantly different among sites. The incidence estimate for SC was 2.6 persons-years. Infection in recent or younger cases showed no association with clade C. Surveillance DRM was observed in 8.3% (95% CI 5-13), mostly to NNRTIs. Clade F pol genomes had significantly more primary DRM.
机译：HIV-1 B在巴西占主导地位，但该国南部越来越多地报告HIV-1C。但是，许多与进化枝C簇集的样品实际上是重组体，在RT处具有小的B片段（CRF31）。分析了三个城市中艾滋病患病率最高的样本（209）。 HIV RNA的部分聚合酶序列使得确定HIV进化枝和重组模式以及鉴定原发性耐药性突变（DRM）成为可能。用BED测定法估计发病率。在所有站点，HIV-1 C和CRF31模式的发生频率是进化枝B的两倍，但在各个站点之间，C和CRF31模式的比例显着不同。 SC的发病率估计为2.6人年。在最近或更年轻的病例中，感染与C进化枝无关。监视DRM的发生率为8.3％（95％CI 5-13），主要发生在NNRTIs。进化枝F pol基因组具有更多的初级DRM。

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