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首页> 外文期刊>AIDS Research and Human Retroviruses >Brain magnetic resonance imaging white matter lesions are frequent in HTLV-I carriers and do not discriminate from HAM/TSP.
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Brain magnetic resonance imaging white matter lesions are frequent in HTLV-I carriers and do not discriminate from HAM/TSP.

机译：脑磁共振成像白质病变在HTLV-1携带者中很常见，不能与HAM / TSP区分。

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摘要

Human T lymphotropic virus (HTLV)-I is known to cause HTLV-I-associated myelopathy/tropical spastic paraparesis (HAM/TSP) and other pronounced disease in less than 4% of those infected. However, evidence is accumulating that a proportion of HTLV-I carriers have neurological and urological symptoms without fulfilling criteria for HAM/TSP. Brain white matter (WM) lesions on magnetic resonance imaging (MRI) are frequently seen in HAM/TSP. HTLV-I carriers with MRI scans for other neurological diagnoses have WM lesions more frequently than expected. We studied 10 patients with HAM/TSP and 20 HTLV-I carriers without overt neurological disease and evaluated clinical characteristics, viral load, total, small, large, confluent WM lesion number, and lesion volume on MRI. Cerebral WM lesions were found in of 85% of HTLV-I carriers and 80% of HAM/TSP patients. Lesion number, size or location was no different between carriers and HAM/TSP. Cognitive function was lower in HAM/TSP (p = 0.045) but did not correlate with WM lesion number. Viral load and peripheral blood mononuclear cell interferon production correlated positively (p = 0.001) but did not correlate with lesion number or volume. Conventional brain MRI frequently shows WM lesions in HTLV-I-infected individuals suggesting potential early central nervous system inflammation with rare development of progressive disease.
机译：已知人类T淋巴病毒（HTLV）-1在少于4％的受感染者中引起HTLV-1相关性脊髓病/热带痉挛性轻瘫（HAM / TSP）和其他明显疾病。但是，越来越多的证据表明，一部分HTLV-1携带者具有神经和泌尿系统症状，但不符合HAM / TSP的标准。 HAM / TSP中经常出现磁共振成像（MRI）上的脑白质（WM）病变。带有MRI扫描以进行其他神经系统诊断的HTLV-1携带者出现WM病变的频率高于预期。我们研究了10例HAM / TSP患者和20例无明显神经系统疾病的HTLV-I携带者，并在MRI上评估了临床特征，病毒载量，总，小，大，融合WM病变数和病变体积。在85％的HTLV-1携带者和80％的HAM / TSP患者中发现了脑WM病变。载体和HAM / TSP之间的病变数目，大小或位置没有区别。 HAM / TSP的认知功能较低（p = 0.045），但与WM病变数无关。病毒载量和外周血单核细胞干扰素产生呈正相关（p = 0.001），但与病灶数目或病变量无关。传统的脑部MRI经常显示感染HTLV-1的个体出现WM病变，提示潜在的早期中枢神经系统发炎，很少发生进行性疾病。

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