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首页> 外文期刊>AIDS Research and Human Retroviruses >HIV-1 Genetic Variants in the Russian Far East
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HIV-1 Genetic Variants in the Russian Far East

机译：俄罗斯远东地区的HIV-1基因变异

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A molecular analysis of HIV-1 subtypes and recombinants circulating in cities in the Russian Far East was performed. The study included samples from 201 outpatients from Vladivostok, Khabarovsk, and Blagoveshchensk. In most parts of Russia, patients are infected with HIV-1 subtype A, known as the IDU-A variant. Subtype B, including the IDU-B variant, is rare in Russia but widespread in the Ukraine, and the CRF02_AG is prevalent in Central Asian countries and Siberia, Russia. One of the challenges of this study in the Far East was to determine whether the molecular landscape of HIV infection in this region is influenced by the bordering countries, including China and Japan, where a distinct set of HIV subtypes is circulating, such as B', C, and CRF01_AE. The distribution of HIV-1 genetic variants in the cities studied was as follows: subtype A (IDU-A), 55.7%; subtype B, 25.3% (IDU-B variant—24.3%); subtype C, 10.0%; CRF02_AG, 1.5%; and CRF63_02Al, 7.5%. A phylogenetic analysis confirmed the relationship of subtype A viruses with the IDU-A variant predominating in Ukraine, Russia and other former Soviet Union (FSU) countries, of subtype B viruses with IDU-B in the Ukraine and of CRF02_AG variants with variants in Uzbekistan, Russia, and other former USSR countries. Subtype C sequences were not uniform, and most clustered between each other and HIV-1 sequences originating from Africa; there was only one sample possibly related to Chinese variants. Thus, despite close cultural and commercial relationships among Russia, China, and Japan, the distribution of HIV-1 subtypes in the Russian Far East is still primarily influenced by contacts with the countries of the former USSR.
机译：进行了在俄罗斯远东地区城市中传播的HIV-1亚型和重组子的分子分析。该研究包括了符拉迪沃斯托克（Vladivostok），哈巴罗夫斯克（Khabarovsk）和布拉戈维申斯克（Blagoveshchensk）的201位门诊患者的样本。在俄罗斯大部分地区，患者感染了HIV-1 A型亚型，即IDU-A变体。 B亚型，包括IDU-B变体，在俄罗斯很少见，但在乌克兰广泛流行，CRF02_AG在中亚国家和俄罗斯西伯利亚很普遍。这项在远东地区的研究面临的挑战之一是确定该地区艾滋病毒感染的分子格局是否受到毗邻国家（包括中国和日本）的影响，这些国家正在传播一系列独特的艾滋病毒亚型，例如B' ，C和CRF01_AE。在研究城市中，HIV-1遗传变异的分布如下：A型（IDU-A），占55.7％; B亚型，25.3％（IDU-B变体-24.3％）; C型，10.0％; CRF02_AG，1.5％;和CRF63_02A1，7.5％。系统发育分析确认了在乌克兰，俄罗斯和其他前苏联（FSU）国家占主导地位的A亚型病毒与IDU-A变异体，在乌克兰与具有IDU-B的B亚型病毒以及在乌兹别克斯坦具有CRF02_AG变异体的关系，俄罗斯和其他前苏联国家。 C型亚型序列不统一，并且大多数彼此聚集成源于非洲的HIV-1序列。只有一个样本可能与中国变体有关。因此，尽管俄罗斯，中国和日本之间有着密切的文化和商业关系，但俄罗斯远东地区HIV-1亚型的分布仍然主要受到与前苏联国家的接触的影响。

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