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首页> 外文期刊>AIDS Research and Human Retroviruses >Change in the Prevalence of HIV-1 and the Rate of Transmitted Drug-Resistant HIV-1 in Haiphong, Northern Vietnam
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Change in the Prevalence of HIV-1 and the Rate of Transmitted Drug-Resistant HIV-1 in Haiphong, Northern Vietnam

机译:越南北部海防市HIV-1流行率和耐药性HIV-1传播率的变化

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摘要

We previously reported a significant decrease in HIV-1 prevalence, with no increase in drug-resistant HIV-1 among injecting drug users (IDU), female sexworkers (FSW), and blood donors (BD), in Haiphong, Vietnam, from 2007 to 2009. In 2012, 388 IDU, 51 FSW, and 200 BD were recruited for further analysis. None had a history of antiretroviral treatment. From 2007 to 2012, HIV-1 prevalence was reduced from 35.9% to 18.6% (p < 0.001), 23.1% to 9.8% (p < 0.05), and 2.9% to 1%(p = 0.29) in IDU, FSW, and BD, respectively. Of 79 anti-HIV-1 antibody-positive samples, 61 were successfully analyzed for the pol-reverse transcriptase (RT) region. All HIV-1 strains were CRF01_AE. Nonnucleoside RT inhibitor-resistant mutations, Y181C/I, were detected in three subjects; one had the nucleoside RT inhibitor-resistant mutations L74V and M184V and one had E138K. The prevalence of transmitted drug-resistant HIV-1 in Haiphong increased slightly from 1.8% in 2007 to 6.6% in 2012 (p = 0.06).
机译:从2007年开始,我们在越南海防市的注射吸毒者(IDU),女性性工作者(FSW)和献血者(BD)中,HIV-1的患病率显着下降,而抗药性HIV-1却没有增加。到2009年。2012年,招募了388个IDU,51个FSW和200个BD进行进一步分析。没有人有抗逆转录病毒治疗史。从2007年到2012年,IDU,FSW中HIV-1的流行率从35.9%降低到18.6%(p <0.001),从23.1%降低到9.8%(p <0.05),从2.9%降低到1%(p = 0.29),和BD。在79个抗HIV-1抗体阳性样品中,成功分析了61个pol逆转录酶(RT)区域。所有HIV-1菌株均为CRF01_AE。在三名受试者中检测到非核苷类RT抑制剂耐药突变Y181C / I。一种具有核苷RT抑制剂抗性突变L74V和M184V,另一种具有E138K。海防市传播的抗药性HIV-1的患病率从2007年的1.8%略增至2012年的6.6%(p = 0.06)。

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