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首页> 外文期刊>AIDS Research and Human Retroviruses >Viral Genetic Diversity and Polymorphisms in a Cohort of HIV-1-Infected Patients Eligible for Initiation of Antiretroviral Therapy in Abuja, Nigeria
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Viral Genetic Diversity and Polymorphisms in a Cohort of HIV-1-Infected Patients Eligible for Initiation of Antiretroviral Therapy in Abuja, Nigeria

机译：尼日利亚阿布贾有资格开始抗逆转录病毒治疗的一组HIV-1感染患者的病毒遗传多样性和多态性

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Studying the genetic diversity and natural polymorphisms of HIV-1 would benefit our understanding of HIV drug resistance (HIVDR) development and predict treatment outcomes. In this study, we have characterized the HIV-1 genetic diversity and natural polymorphisms at the 5 ' region of the pol gene encompassing the protease (PR) and reverse transcriptase (RT) from 271 plasma specimens collected in 2008 from HIV-1-infected patients who were eligible for initiating antiretroviral therapy in Abuja (Nigeria). The analysis indicated that the predominant subtype was subtype G (31.0%), followed by CRF02-AG (19.2 %), CRF43-02G (18.5%), and A/CRF36-cpx (11.4%); the remaining (19.9%) were other subtypes and circulating (CRF) and unique (URF) recombinant forms. Recombinant viruses (68.6%) were the major viral strains in the region. Eighty-four subtype G sequences were further mainly classified into two major and two minor clusters; sequences in the two major clusters were closely related to the HIV-1 strains in two of the three major subtype G clusters detected worldwide. Those in the two minor clusters appear to be new subtype G strains circulating only in Abuja. The pretreatment DR prevalence was <3%; however, numerous natural polymorphisms were present. Eleven polymorphic mutations (G16E, K20I, L23P, E35D, M36I, N37D/S/T, R57K, L63P, and V82I) were detected in the PR that were subtype or CRF specific while only three mutations (D123N, I135T, and I135V) were identified in the RT. Overall, this study indicates an evolving HIV-1 epidemic in Abuja with recombinant viruses becoming the dominant strains and the emergence of new subtype G strains; pretreatment HIVDR was low and the occurrence of natural polymorphism in the PR region was subtype or CRF dependent.
机译：研究HIV-1的遗传多样性和天然多态性将有助于我们了解HIV耐药性（HIVDR）的发展并预测治疗结果。在这项研究中，我们已经表征了pol基因5'区域的HIV-1遗传多样性和自然多态性，包括2008年从HIV-1感染者收集的271个血浆标本中的蛋白酶（PR）和逆转录酶（RT）。有资格在阿布贾（尼日利亚）开始抗逆转录病毒治疗的患者。分析表明，主要的亚型是G亚型（31.0％），其次是CRF02-AG（19.2％），CRF43-02G（18.5％）和A / CRF36-cpx（11.4％）;其余（19.9％）是其他亚型，循环（CRF）和独特（URF）重组形式。重组病毒（68.6％）是该地区的主要病毒株。八十四个亚型G序列进一步主要分为两个主要和两个次要簇。在全球范围内检测到的三个主要亚型G簇中的两个中，两个主要簇中的序列与HIV-1毒株密切相关。在两个较小簇中的那些似乎是仅在阿布贾流通的新的G型亚型。预处理DR的患病率＜3％;但是，存在许多自然多态性。在PR中检测到11种亚型或CRF特异的多态性突变（G16E，K20I，L23P，E35D，M36I，N37D / S / T，R57K，L63P和V82I），而只有3种突变（D123N，I135T和I135V）在RT中被确定。总体而言，这项研究表明，阿布贾正在发生HIV-1流行病，重组病毒成为主要病毒，并出现了新的G型亚型。预处理HIVDR较低，PR区天然多态性的发生是亚型或CRF依赖性的。

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