Induction of HIV type 1 expression correlates with T cell responsiveness to mycobacteria in patients coinfected with HIV type 1 and Mycobacterium tuberculosis.

Canaday DH; Wu M; Lu S; Aung H; Peters P; Baseke J; Mackay W; Mayanja-Kizza H; Toossi Z

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Induction of HIV type 1 expression correlates with T cell responsiveness to mycobacteria in patients coinfected with HIV type 1 and Mycobacterium tuberculosis.

机译：在感染了HIV 1型和结核分枝杆菌的患者中，HIV 1型表达的诱导与T细胞对分枝杆菌的反应性相关。

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An in vitro mononuclear cell system to model the microenvironment of coinfection with HIV-1 and Mycobacterium tuberculosis (MTB) was developed. This cellular system was used to assess the interaction of MTB-infected monocytes and T cells from dually infected HIV-1/TB patients with pulmonary tuberculosis (TB). Subjects with higher induction of HIV-1 gag/pol mRNA expression after MTB stimulation had increased MTB-specific T cell IFN-gamma and TNF-alpha production. Lack of HIV-1 mRNA induction did not correlate with increased induction of regulatory T cells (T-reg) as measured by MTB-induced Foxp3 mRNA. HIV-1 induction did not significantly correlate with clinical parameters including plasma HIV-1 viral load or CD4(+) T cell count. These data model MTB-induced HIV-1 replication at the microenvironment of MTB reactivation/infection. The data suggest that the magnitude of MTB-specific T cell responses drives local viral pathogenesis regardless of the stage of HIV-1 disease as reflected by plasma viral load or CD4(+) T cell count.

机译：开发了一种体外单核细胞系统，以模拟与HIV-1和结核分枝杆菌（MTB）共同感染的微环境。该细胞系统用于评估双重感染的HIV-1 / TB肺结核（TB）患者的MTB感染的单核细胞和T细胞的相互作用。在MTB刺激后，具有较高HIV-1 gag / pol mRNA表达诱导能力的受试者的MTB特异性T细胞IFN-γ和TNF-α产生增加。如通过MTB诱导的Foxp3 mRNA所测量的，缺乏HIV-1 mRNA诱导与调节性T细胞（T-reg）诱导增加无关。 HIV-1诱导与临床参数（包括血浆HIV-1病毒载量或CD4（+）T细胞计数）没有显着相关性。这些数据在MTB激活/感染的微环境中模拟了MTB诱导的HIV-1复制。数据表明，无论血浆HIV负荷或CD4（+）T细胞计数如何反映，无论HIV-1疾病的阶段如何，MTB特异性T细胞反应的幅度都会驱动局部病毒发病。

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《AIDS Research and Human Retroviruses》 |2009年第2期|共4页
作者
Canaday DH; Wu M; Lu S; Aung H; Peters P; Baseke J; Mackay W; Mayanja-Kizza H; Toossi Z;
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正文语种 eng
中图分类传染病;
关键词
Adolescent; Adult; Animals; CD4 Lymphocyte Count; Female; Forkhead Transcription Factors; 成年人; 动物; CD4淋巴细胞计数; HIV感染; 分支杆菌; 结核; T淋巴细胞亚群; T淋巴细胞;

机译：Adolescent;Adult;Animals;CD4 Lymphocyte Count;Female;Forkhead Transcription Factors;成年人;动物;CD4淋巴细胞计数;HIV感染;分支杆菌;结核;T淋巴细胞亚群;T淋巴细胞;

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专利

1. Induction of HIV type 1 expression correlates with T cell responsiveness to mycobacteria in patients coinfected with HIV type 1 and Mycobacterium tuberculosis. [J] . Canaday DH, Wu M, Lu S, AIDS Research and Human Retroviruses . 2009,第2期

机译：在感染了HIV 1型和结核分枝杆菌的患者中，HIV 1型表达的诱导与T细胞对分枝杆菌的反应性相关。
2. Inability to detect human T cell lymphotropic virus type 2-specific antibodies in a patient coinfected with HIV-1, human T cell lymphotropic virus type 1, human T cell lymphotropic virus type 2, and hepatitis C virus [J] . Caterino-De-AraujoA., MagriM.C., SatoN.S., AIDS Research and Human Retroviruses . 2014,第1期

机译：无法在感染了HIV-1、1型人T细胞淋巴病毒，2型人T细胞淋巴病毒的患者中检测到2型人T细胞淋巴病毒特异性抗体
3. Evaluation of circulating natural type 1 interferon-producing cells in HIV/GBV-C and HIV/HCV coinfected patients: a preliminary study. [J] . Haji-Molla-Hoseini M, Pourfathollah AA, Mohraz M, Archives of medical research . 2007,第8期

机译：在HIV / GBV-C和HIV / HCV合并感染的患者中评估循环产生的天然1型干扰素的细胞：一项初步研究。
4. The Use of Surrogate Markers to Predict Degree of Liver Damage in HIV/HCV Coinfected Patients [C] . S. Kimmel, M. Hoffman Terry International AIDS Conference . 2004

机译：使用替代标记以预测肝脏损伤患者肝损伤程度
5. IgE anti-HIV-1 in serum of HIV-1 infected children inhibits HIV-1 production in vitro and IgE mediates cytotoxicity against lymphoma cells expressing HIV-1 and peripheral blood mononuclear cells from an HIV-1 seropositive patient [D] . Bluth, Martin Heath. 1997

机译：HIV-1感染儿童血清中的IgE抗HIV-1抑制了HIV-1的体外产生，IgE介导了对HIV-1血清反应阳性患者表达HIV-1的淋巴瘤细胞和外周血单核细胞的细胞毒性
6. Short Communication: Induction of HIV Type 1 Expression Correlates with T Cell Responsiveness to Mycobacteria in Patients Coinfected with HIV Type 1 and Mycobacterium tuberculosis [O] . David H. Canaday, Mianda Wu, Shigou Lu, -1

机译：简短交流：HIV 1型和结核分枝杆菌合并感染患者的HIV 1型表达诱导与T细胞对分枝杆菌的反应性相关
7. Human T Cell Lymphotropic Virus Type 2a Strains Among HIV Type 1-Coinfected Patients from Brazil Have Originated Mostly from Brazilian Amerindians [O] . Mariana Cavalheiro Magri, Luis Fernando de Macedo Brigido, Helena Kaminami Morimoto, 2013

机译：人类T细胞淋巴细胞型病毒2A型艾滋病毒1型兴奋剂患者的菌株主要来自巴西阿梅林德

Induction of HIV type 1 expression correlates with T cell responsiveness to mycobacteria in patients coinfected with HIV type 1 and Mycobacterium tuberculosis.

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