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首页> 外文期刊>AIDS Research and Human Retroviruses >A decrease in albumin in early SIV infection is related to viral pathogenicity.
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A decrease in albumin in early SIV infection is related to viral pathogenicity.

机译：早期SIV感染中白蛋白的减少与病毒的致病性有关。

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A decrease in circulating albumin levels after seroconversion has been reported as a predictor of disease progression in HIV-infected adults. We hypothesized that a similar decrease would be seen in pig-tailed macaques in early SIV infection, and that the degree of this decrease would be related to the pathogenicity of the infecting viral strain. Ten juvenile pig-tailed macaques were previously inoculated with virus derived from molecular clones representing different stages of infection: early (SIVMneCL8, n = 2), intermediate (SIVMne35wkSU, n = 2), late blood (SIVMne170, n = 3), or late lymph node (SIVMne027, n = 3). Albumin was measured in stored samples. Changes from baseline were evaluated by paired sample t tests and by linear regression with generalized estimating equations (GEE). Albumin levels decreased in the week after SIV inoculation (p = 0.02), increased above baseline at week 5, then fell, returning below baseline by week 16 (p = 0.03). In GEE modeling, albumin decreased significantly in both early and chronic infection (weeks 0-3, p < 0.001; weeks 5-16, p = 0.004) and this change differed significantly between infections caused by late versus early or intermediate virus variants (weeks 0-3, p = 0.002; weeks 5-16, p = 0.001). A decrease in albumin levels occurs in both early and chronic SIV infection, and is more marked in macaques infected with more pathogenic virus variants. These results suggest that both early and late events in SIV pathogenesis are influenced by properties of the infecting viral strain.
机译：据报道，血清转化后循环白蛋白水平的降低是HIV感染成年人疾病进展的预测指标。我们假设在早期SIV感染中在猪尾猕猴中会看到类似的减少，并且这种减少的程度将与感染病毒株的致病性有关。预先用代表不同感染阶段的分子克隆的病毒接种了十只少年猪尾猕猴：早期（SIVMneCL8，n = 2），中间（SIVMne35wkSU，n = 2），晚期血液（SIVMne170，n = 3），或晚期淋巴结转移（SIVMne027，n = 3）。在储存的样品中测量白蛋白。通过配对样本t检验和带有广义估计方程（GEE）的线性回归来评估基线的变化。 SIV接种后一周中白蛋白水平下降（p = 0.02），在第5周时高于基线，然后下降，到第16周时恢复低于基线（p = 0.03）。在GEE模型中，早期和慢性感染的白蛋白均显着下降（第0-3周，p <0.001;第5-16周，p = 0.004），并且这种变化在由晚期，早期或中间病毒变体引起的感染之间（周0-3，p = 0.002; 5-16周，p = 0.001）。白蛋白水平的降低在早期和慢性SIV感染中均发生，并且在感染了更多病原性病毒变体的猕猴中更为明显。这些结果表明，SIV发病机理中的早期事件和晚期事件均受感染病毒株的特性影响。

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