Short Communication: Evaluation of the Effect of Enfuvirtide in 11 HIV-1 Vertically Infected Pediatric Patients Outside Clinical Trials

C. Palladino; V. Briz; M.I. Gonzalez Tome; J.A. Leon Leal

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Short Communication: Evaluation of the Effect of Enfuvirtide in 11 HIV-1 Vertically Infected Pediatric Patients Outside Clinical Trials

机译：简短交流：恩夫韦肽在11例临床试验以外的垂直感染HIV-1儿科患者中的疗效评估

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The effect of enfuvirtide (ENF) in 11 HIV-1 heavily antiretroviral-experienced children and adolescents enrolled in the HIV-1 Paediatric Spanish cohort was further investigated. Patients who received ENF with novel drugs (etravirine, darunavir, and/or tipranavir) reached and maintained undetectable plasma HIV-1 RNA levels and showed immunological recovery within the first 3 months of therapy that was maintained during the follow-up. Viremia was not fully suppressed in patients who did not combine ENF with novel drugs but interestingly, immunological benefit was observed in half of these patients. Therefore, ENF showed a greater and more stable efficacy when administrated with novel drugs.

机译：进一步研究了enfuvirtide（ENF）对11名HIV-1小儿抗逆转录病毒药物经验丰富的儿童和青少年在西班牙HIV-1小儿队列中的作用。接受ENF新药（依曲韦林，达那那韦和/或Tipranavir）治疗的患者达到并维持了无法检测到的血浆HIV-1 RNA水平，并在随访的最初3个月内显示出免疫学恢复。未将ENF与新药合用的患者并未完全抑制病毒血症，但有趣的是，这些患者中有一半具有免疫学益处。因此，ENF与新药合用时显示出更大，更稳定的功效。

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《AIDS Research and Human Retroviruses》 |2010年第3期|共6页
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C. Palladino; V. Briz; M.I. Gonzalez Tome; J.A. Leon Leal;
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1. Short Communication: Evaluation of the Effect of Enfuvirtide in 11 HIV-1 Vertically Infected Pediatric Patients Outside Clinical Trials [J] . C. Palladino, V. Briz, M.I. Gonzalez Tome, AIDS Research and Human Retroviruses . 2010,第3期

机译：简短交流：恩夫韦肽在11例临床试验以外的垂直感染HIV-1儿科患者中的疗效评估
2. Short communication: Effectiveness at 48 weeks of switching from enfuvirtide to raltegravir in virologically suppressed multidrug-resistant HIV type 1-infected patients in a Brazilian cohort [J] . WestinM.R., BiscioneF., RibeiroK.M., AIDS Research and Human Retroviruses . 2014,第2期

机译：简短交流：在巴西队列中，在病毒学上抑制了多重耐药性的HIV 1型感染的患者中，从恩夫韦肽转用raltegravir治疗48周时的有效性
3. Durable efficacy of enfuvirtide over 48 weeks in heavily treatment-experienced HIV-1-infected patients in the T-20 versus optimized background regimen only 1 and 2 clinical trials. [J] . Nelson M, Arasteh K, Clotet B, JAIDS: Journal of acquired immune deficiency syndromes . 2005,第4期

机译：恩夫韦肽在经过T-20治疗且大量接受过HIV-1感染的患者中经过48周的持久疗效，而优化背景方案仅进行了1和2次临床试验。
4. Patient in control in clinical trials - European initiatives for improving patient empowerment in clinical trials through technical implementation of legal norms [C] . Forgo Nikolaus, Goralczyk Magdalena, Hanold Stefanie Annual Conference of Japanese Society for Medical and Biological Engineering;Annual International Conference of the IEEE Engineering in Medicine and Biology Society . 2013

机译：在临床试验中控制患者-通过法律规范的技术实施来提高临床试验中患者的能力的欧洲倡议
5. The impact of pharmacodynamic parameters on prediction of clinical outcome in HIV-1 infected patients and HCV patients with HIV co-infection. [D] . Kim, Tae Eun. 2012

机译：药效学参数对HIV-1感染的患者和HCV合并感染的HCV患者的临床结局预测的影响。
6. Impact of the HIV-1 env Genetic Context outside HR1–HR2 on Resistance to the Fusion Inhibitor Enfuvirtide and Viral Infectivity in Clinical Isolates [O] . Franky Baatz, Monique Nijhuis, Morgane Lemaire, 2011

机译：HR1-HR2以外的HIV-1 env遗传背景对临床分离株对融合抑制剂Enfuvirtide的抵抗力和病毒感染性的影响
7. Durable efficacy of enfuvirtide over 48 weeks in heavily treatment-experienced HIV-1-infected patients in the T-20 versus optimized background regimen only 1 and 2 clinical trials [O] . Nelson Mark, Arastéh Keikawus, Clotet Bonaventura, 2005

机译：恩夫韦肽在经过T-20治疗的经历过大量治疗的HIV-1感染患者中超过48周的持久疗效，而优化背景方案仅进行了1和2次临床试验

Short Communication: Evaluation of the Effect of Enfuvirtide in 11 HIV-1 Vertically Infected Pediatric Patients Outside Clinical Trials

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