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首页> 外文期刊>AIDS Research and Human Retroviruses >Short communication: Lack of immune response in rapid progressor morphine-dependent and SIV/SHIV-infected rhesus macaques is correlated with downregulation of TH1 cytokines.
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Short communication: Lack of immune response in rapid progressor morphine-dependent and SIV/SHIV-infected rhesus macaques is correlated with downregulation of TH1 cytokines.

机译：简短的交流：快速进展的吗啡依赖性和SIV / SHIV感染的恒河猴猕猴缺乏免疫应答与TH1细胞因子的下调有关。

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摘要

Our previous studies have shown two distinct disease patterns (rapid and normal onset of clinical symptoms) in morphine-dependent SHIV/SIV-inoculated rhesus macaques. We have also shown that control as well as 50% of morphine-dependent macaques (normal progressor) developed humoral and cellular immune responses whereas the other half of the morphine-dependent macaques (rapid progressor) did not develop antiviral immune responses after infection with SIV/SHIV. In the present study, we analyzed the association between cytokine production, immune response, and disease progression. To study the immunological effects of morphine at cytokine levels in the context of a lentiviral infection, we inoculated rhesus macaques with a mixture of SHIV(KU-18), SHIV(89.6)P, and SIV/17E-Fr. These animals were followed for a period of 56 weeks for cytokine level production in plasma. Drug-dependent rapid disease progressors exhibited an increase in IL-18 and IL-1Ra and a decrease in IL-12 levels in the plasma. Morphine-dependent normal progressors and control macaques exhibited an increase in both IL-18 and IL-12, whereas IL-Ra levels remained constant throughout the observation period. These results suggest that rapid disease progression in relation to morphine dependency may be the result of an altered cytokine profile.
机译：我们以前的研究表明，在吗啡依赖性SHIV / SIV接种的猕猴中出现两种不同的疾病模式（临床症状的快速发作和正常发作）。我们还显示，感染SIV后，对照以及50％的吗啡依赖性猕猴（正常进展者）会产生体液和细胞免疫反应，而另一半吗啡依赖性猕猴（快速进展者）则不会产生抗病毒免疫反应。 / SHIV。在本研究中，我们分析了细胞因子产生，免疫反应和疾病进展之间的关联。为了研究慢病毒感染情况下吗啡在细胞因子水平上的免疫学作用，我们用SHIV（KU-18），SHIV（89.6）P和SIV / 17E-Fr的混合物接种了猕猴。跟踪这些动物56周，以产生血浆​​中的细胞因子水平。药物依赖性快速疾病进展者血浆中IL-18和IL-1Ra升高，IL-12水平降低。吗啡依赖的正常进行者和对照猕猴均表现出IL-18和IL-12均升高，而IL-Ra水平在整个观察期内保持恒定。这些结果表明，与吗啡依赖性有关的疾病快速进展可能是细胞因子谱改变的结果。

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