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首页> 外文期刊>AIDS Research and Human Retroviruses >Cystatin C and Baseline Renal Function Among HIV-Infected Persons in the SUN Study
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Cystatin C and Baseline Renal Function Among HIV-Infected Persons in the SUN Study

机译：SUN研究中HIV感染者的胱抑素C和基线肾功能

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In the combination antiretroviral therapy (cART) era, renal dysfunction remains common. The Study to Understand the Natural History of HIV/AIDS in the Era of Effective Therapy (SUN) (ClinicalTrials.gov number, NCT00146419) is a prospective observational cohort study of HIV-infected adults. At baseline, comprehensive data were collected, including cystatin C and measures of renal function. Univariate and multivariate regression analyses were performed to identify factors associated with baseline renal dysfunction [estimated glomerular filtration rate (eGFR) < 90 ml/min/1.73 m~2 calculated using the simplified Modification of Diet in Renal Disease equation] and elevated cystatin C (>1.0mg/liter) in a cross-sectional analysis. Among 670 subjects with complete data (mean age 41 years, mean CD4 cell count 530 cells/mm~3, 79% prescribed cART), the mean eGFR was 96.8 ml/min/1.73 m~2. Forty percent of subjects had renal dysfunction; 3.3% had chronic kidney disease (eGFR < 60 ml/min/ 1.73 m~2). Elevated cystatin C was present in 18% of subjects. In multivariate analysis, renal dysfunction was associated with older age, non-Hispanic white race/ethnicity, higher body mass index (BMI), hypertension, higher cystatin C levels, and current prescription of ritonavir. Factors associated with elevated cystatin C included hepatitis C coinfection, hypertension, current smoking, older age, current tenofovir use, detectable plasma HIV RNA, and elevated microalbuminuria. The prevalence of chronic kidney disease (CKD) was low in this contemporary HIV cohort. However, mild to moderate renal dysfunction was common despite the widespread use of cART.
机译：在联合抗逆转录病毒疗法（cART）时代，肾功能不全仍然很常见。了解有效治疗时代（SUN）的HIV / AIDS自然史的研究（ClinicalTrials.gov编号，NCT00146419）是一项针对HIV感染成年人的前瞻性观察队列研究。在基线时，收集了包括胱抑素C和肾功能指标在内的综合数据。进行单因素和多因素回归分析，以发现与基线肾功能不全有关的因素[使用简化的《饮食中肾脏疾病方程式计算得出的估计肾小球滤过率（eGFR）<90 ml / min / 1.73 m〜2》]和胱抑素C（ > 1.0mg / L）的横截面分析。在670名具有完整数据的受试者中（平均年龄41岁，平均CD4细胞计数为530细胞/ mm〜3，79％的处方cART），平均eGFR为96.8 ml / min / 1.73 m〜2。 40％的受试者患有肾功能不全; 3.3％患有慢性肾脏疾病（eGFR <60 ml / min / 1.73 m〜2）。 18％的受试者存在半胱氨酸蛋白酶抑制剂C升高。在多变量分析中，肾功能不全与年龄较大，非西班牙裔白人/种族，较高的体重指数（BMI），高血压，半胱氨酸蛋白酶抑制剂C水平和目前的利托那韦处方有关。胱抑素C升高的相关因素包括丙型肝炎合并感染，高血压，当前吸烟，年龄较大，当前使用替诺福韦，可检测到的血浆HIV RNA和微量白蛋白尿升高。在这个当代的HIV人群中，慢性肾脏疾病（CKD）的患病率较低。然而，尽管广泛使用cART，轻度至中度肾功能不全仍很常见。

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