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首页> 外文期刊>AIDS Research and Human Retroviruses >Comparison of transcriptional profiles between CD4+ and CD8 + T cells in HIV type 1-infected patients
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Comparison of transcriptional profiles between CD4+ and CD8 + T cells in HIV type 1-infected patients

机译：HIV 1型感染患者CD4 +和CD8 + T细胞转录谱的比较

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The CD4+CD8+ T cell ratio is altered when HIV-1 infects the human immune system. However, the exact mechanisms of how CD4 + and CD8+ T cells participate in HIV infection are still unknown. This study used bioinformatics methods to compare the transcriptional profiles between CD4+ and CD8+ T cells in HIV-1-infected patients in order to explore the potential molecular mechanisms of CD4 + and CD8+ T cells in HIV-1 infection. We found that expression patterns of differentially expressed genes (DEG) in CD4+ T cells were dramatically different from those in CD8+ T cells. We also constructed protein-protein interaction (PPI) networks to extract functional modules at each stage, and found that some of the important genes such as BRCA1 were central hubs of the modules. Finally, we applied functional annotation to the modules and found that CD4+/CD8+ T cells played critical roles in regulating the cell cycle and other cellular pathways. Thus, this study would greatly further our understanding of the roles of T cells in HIV infection, and provide potential clues for developing AIDS vaccines in the future.
机译：当HIV-1感染人类免疫系统时，CD4 + CD8 + T细胞比率就会改变。但是，CD4 +和CD8 + T细胞如何参与HIV感染的确切机制仍然未知。这项研究使用生物信息学方法比较了HIV-1感染患者中CD4 +和CD8 + T细胞之间的转录谱，以探讨HIV-1感染中CD4 +和CD8 + T细胞的潜在分子机制。我们发现，CD4 + T细胞中差异表达基因（DEG）的表达模式与CD8 + T细胞中的差异显着。我们还构建了蛋白质-蛋白质相互作用（PPI）网络来提取每个阶段的功能模块，并发现一些重要的基因（例如BRCA1）是模块的中心枢纽。最后，我们将功能注释应用于模块，发现CD4 + / CD8 + T细胞在调节细胞周期和其他细胞途径中起着关键作用。因此，这项研究将大大加深我们对T细胞在HIV感染中的作用的了解，并为将来开发AIDS疫苗提供潜在的线索。

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