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首页> 外文期刊>AIDS Research and Human Retroviruses >HIV-1 Genetic Diversity and Transmitted Drug Resistance Among Recently Infected Individuals at Men Who Have Sex with Men Sentinel Surveillance Points in Hebei Province, China
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HIV-1 Genetic Diversity and Transmitted Drug Resistance Among Recently Infected Individuals at Men Who Have Sex with Men Sentinel Surveillance Points in Hebei Province, China

机译：中国河北省与男子前哨监视点发生性关系的男子中近期感染者的HIV-1遗传多样性和传播的耐药性

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摘要

For this study, 50 HIV-1 plasma samples of recently infected men who have sex with men (MSM) were amplified and sequenced. Multiple subtypes were identified by phylogenetic analyses of HIV-1 gag, env, and pol gene regions, including CRF01_AE (56.0%), CRF07_BC (30.0%), subtype B (12.0%), and unique recombinant forms (URFs, 6.0%). CRF01_AE was the most frequent genotype in the epidemic. Three recombination patterns of URFs were identified: 01BC, 01B, and 01C. The rate of HIV-1 transmitted drug resistance (TDR) mutation (M46L) was 2.08% (1/48). URFs and TDR first identified in this study suggest that HIV-1 prevalence is more and more complicated, and HIV-1 drug-resistant strains have begun to spread among at risk populations in Hebei. Our findings can provide vital information for an efficient surveillance system and strategic HIV prevention and control measures in China by revealing the evolutionary status and HIV-1 TDR of HIV-1 strains among recently infected MSM in Hebei Province.
机译：在本研究中，扩增并测序了最近感染的与男性发生性关系的男性的50个HIV-1血浆样品并进行了测序。通过对HIV-1 gag，env和pol基因区域的系统发育分析，鉴定出多种亚型，包括CRF01_AE（56.0％），CRF07_BC（30.0％），B亚型（12.0％）和独特的重组形式（URFs，6.0％） 。 CRF01_AE是该流行病中最常见的基因型。确定了三种URF重组模式：01BC，01B和01C。 HIV-1传播的耐药性（TDR）突变（M46L）的发生率为2.08％（1/48）。在这项研究中首次发现的URF和TDR表明，HIV-1的流行越来越复杂，HIV-1耐药株已开始在河北高危人群中传播。通过揭示河北省最近感染的MSM中HIV-1菌株的进化状况和HIV-1 TDR，我们的发现可以为中国的有效监测系统和战略性HIV预防和控制措施提供重要信息。

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