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首页> 外文期刊>AIDS Research and Human Retroviruses >Short communication: high prevalence of drug-resistant human immunodeficiency virus type 1 in treatment-naive patients in Greenland.
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Short communication: high prevalence of drug-resistant human immunodeficiency virus type 1 in treatment-naive patients in Greenland.

机译：简短交流：格陵兰初治患者中耐药性1型人类免疫缺陷病毒的普遍流行。

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摘要

A molecular epidemiologic study of HIV-1 in Greenland showed distinct transmission clusters correlated with demographic and behavioral data. Resistance mutations were found in a majority of the pol sequences. The objective of the present study was to estimate prevalence of drug resistance in Greenland and identify transmission chains by comparing resistance data with phylogeny and treatment history. Of 60 untreated patients, 15 (25%) had primary resistance mutations. The most prevalent mutations were T69D/N (15%), K70R (15%), and M184V (10%). Four possible transmission chains were identified based on phylogeny and mutation profiles. The clusters consisted of treated and untreated patients and showed the same mutation profiles in both resistance and nonresistance positions. Prevalence of transmitted drug resistance in Greenland (25%) is higher than in Denmark where only 3% transmission was observed. Suboptimal use of nucleoside reverse transcriptase inhibitor (NRTI) in Greenland was reflected in the high prevalence of NRTI-related resistance in the patients. A combination of phylogeny and genotypic resistance tests enabled us to study the number of transmissions and how the virus was transmitted. Resistance mutations detected in untreated patients were backed up by the treatment history of index patients in the possible transmission chains and indicated that these drug-resistant variants were in fact transmitted and had not emerged due to unregistered drug intake.
机译：格陵兰岛HIV-1的分子流行病学研究显示，与人群和行为数据相关的独特传播簇。在大多数pol序列中发现了抗性突变。本研究的目的是通过比较耐药性数据与系统发育和治疗史来估计格陵兰的耐药性流行情况并确定传播链。在60例未经治疗的患者中，有15例（25％）具有原发性耐药突变。最普遍的突变是T69D / N（15％），K70R（15％）和M184V（10％）。根据系统发育和突变情况，确定了四个可能的传播链。这些簇由已治疗和未治疗的患者组成，并且在抗药性和非抗药性位置均显示出相同的突变谱。格陵兰的传播耐药性患病率（25％）高于仅观察到3％传播的丹麦。格陵兰人对核苷逆转录酶抑制剂（NRTI）的使用不佳反映在患者中NRTI相关耐药的高患病率中。系统发育和基因型耐药性测试的结合使我们能够研究传播的数量以及病毒的传播方式。在未经治疗的患者中检测到的耐药性突变得到了可能的传播链中索引患者的治疗历史的支持，表明这些耐药性变异实际上已经传播并且由于未注册的药物摄入而未出现。

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