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首页> 外文期刊>AIDS Research and Human Retroviruses >No relationship between TNF-alpha genetic variants and combination antiretroviral therapy-related lipodystrophy syndrome in HIV type 1-infected patients: a case-control study and a meta-analysis.
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No relationship between TNF-alpha genetic variants and combination antiretroviral therapy-related lipodystrophy syndrome in HIV type 1-infected patients: a case-control study and a meta-analysis.

机译：HIV 1型感染患者的TNF-α遗传变异与抗逆转录病毒疗法相关的脂肪营养不良综合征之间无关联：病例对照研究和荟萃分析。

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Tumor necrosis factor alpha (TNF-alpha) is thought to be involved in the pathogenic and metabolic events associated with HIV-1 infection. We assessed whether carriage of the TNF-alpha gene promoter single nucleotide polymorphism (SNP) is associated with lipodystrophy and metabolic derangements in HIV-1-infected patients treated with cART. We also assessed variations in TNF-alpha receptor plasma levels. The study group comprised 286 HIV-1-infected patients (133 with and 153 without lipodystrophy) and 203 uninfected controls (UC). TNF-alpha -238G > A, -308G > A, and -863 C > A SNP were assessed using PCR-RFLPs on white cell DNA. Plasma sTNF-alpha R1 and R2 levels were measured by ELISA. Student's t test, the chi(2) test, Pearson correlations, and the logistic regression test were performed for statistical analysis. The TNF-alpha -308G > A SNP was significantly associated with lipodystrophy in the univariate analysis (p = 0.04). This association, however, was no longer significant in the multivariate analysis. A meta-analysis of the published literature and our own data, which included 284 patients with lipodystrophy and 338 without lipodystrophy, showed that there was no relationship between the TNF-alpha -238G > A and -308G > A SNP and lipodystrophy (p > 0.05 for all comparisons). HIV-1-infected patients had greater sTNF-alpha R2 plasma levels than UC (p = 0.001) whereas sTNF-alpha R1 and R2 levels were not significantly different in both the HIV-1-infected cohorts, lipodystrophy vs. nonlipodystrophy (p = NS). In our cohort of white Spaniards the TNF-alpha -238G > A, -308G > A, and -863C > A SNP were not associated with lipodystrophy in HIV-1-infected patients treated with cART. This finding was replicated in a meta-analysis of the published data, which showed no associations between the TNF-alpha -238G > A and -308G > A SNP and lipodystrophy. In HIV-1-infected patients under cART there is a systemic overproduction of sTNF-alpha R2, which is unrelated to the presence of lipodystrophy.
机译：肿瘤坏死因子α（TNF-alpha）被认为与HIV-1感染相关的致病和代谢事件。我们评估了在接受cART治疗的HIV-1感染患者中，TNF-α基因启动子单核苷酸多态性（SNP）的运输是否与脂肪营养不良和代谢紊乱有关。我们还评估了TNF-α受体血浆水平的变化。该研究组包括286名HIV-1感染患者（133名有脂溢性营养不良和153名无脂肪营养不良）和203名未感染的对照（UC）。使用PCR-RFLP对白细胞DNA评估TNF-alpha -238G> A，-308G> A和-863 C> A SNP。通过ELISA测量血浆sTNF-αR1和R2水平。进行了学生t检验，chi（2）检验，Pearson相关性和逻辑回归检验以进行统计分析。在单变量分析中，TNF-α-308G> A SNP与脂肪营养不良显着相关（p = 0.04）。但是，这种关联在多元分析中不再重要。对已发表的文献和我们自己的数据进行的荟萃分析，其中包括284例有脂肪营养不良的患者和338例没有脂肪营养不良的患者，显示TNF-alpha -238G> A和-308G> A SNP与脂肪营养不良之间没有关系（p>所有比较都为0.05）。被HIV-1感染的患者的血浆sTNF-alpha R2血浆水平高于UC（p = 0.001），而在被HIV-1感染的人群中，脂肪营养不良与非脂肪营养不良的sTNF-alpha R1和R2水平无显着差异（p = NS）。在我们的白色西班牙人队列中，在接受cART治疗的HIV-1感染患者中，TNF-α-238G> A，-308G> A和-863C> A SNP与脂肪营养不良无关。在对已发表数据的荟萃分析中重复了这一发现，该结果表明TNF-α-238G> A和-308G> A SNP与脂肪营养不良之间没有关联。在接受cART的HIV-1感染患者中，系统性生产sTNF-αR2过多，这与脂肪营养不良的存在无关。

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