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首页> 外文期刊>AIDS Research and Human Retroviruses >Profile of patients triply infected with HIV and the hepatitis B and C viruses in the HAART era.
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Profile of patients triply infected with HIV and the hepatitis B and C viruses in the HAART era.

机译：HAART时代三度感染HIV以及乙肝和丙肝病毒的患者的概况。

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HIV-HCV-HBV-coinfected patients were assessed to characterize the viral interactions in the setting of HIV coinfection and in the HAART era. All positive anti-HCV antibody and HBs antigen-positive HIV-infected patients were identified at five HIV clinics. Antihepatitis delta (HDV) antibody, serum HIV RNA, HCV RNA, and HBV DNA quantification and genotype determinations were performed. Out of 67 patients identified 47 (70%) were receiving anti-HBV therapy. HCV RNA and HBV DNA were detectable in 52.5% and 37% of patients, respectively. All possible patterns were found, regardless of anti-HBV therapy. HDV coinfection was associated with undetectable HCV RNA [RR 9.52 (95% CI 1.85-49.01); p = 0.007]. Independent factors predicting undetectable HBV DNA lacked HBeAg [RR 13.94 (95% CI 3.05-63.72); p = 0.001] and use of anti-HBV therapy [RR 11.42 (95% CI 2.43-53.54); p = 0.002]. Replication and genotypes of HCV or HBV had no impact on the replication of the other virus. In conclusion, in this cohort of triple infection (HBV/HCV/HIV) various viral patterns were identified. Spontaneous HCV clearance was frequent, and it was independently associated with HDV coinfection. In the absence of HBV therapy, HBV most often actively replicates. HBV/HCV replication or genotypes were not related to the replication of the other virus.
机译：对HIV-HCV-HBV合并感染的患者进行评估，以表征在HIV合并感染的环境中和HAART时代的病毒相互作用。在五家艾滋病诊所对所有抗HCV抗体阳性和HBs抗原阳性的HIV感染患者进行了鉴定。进行了抗肝炎三角洲（HDV）抗体，血清HIV RNA，HCV RNA和HBV DNA定量和基因型测定。在确定的67名患者中，有47名（70％）正在接受抗HBV治疗。 HCV RNA和HBV DNA分别在52.5％和37％的患者中检出。无论抗HBV疗法如何，都找到了所有可能的模式。 HDV合并感染与无法检测到的HCV RNA相关[RR 9.52（95％CI 1.85-49.01）; p ＝ 0.007]。预测无法检测到的HBV DNA的独立因素缺乏HBeAg [RR 13.94（95％CI 3.05-63.72）; p = 0.001]和使用抗HBV治疗[RR 11.42（95％CI 2.43-53.54）; p = 0.002]。 HCV或HBV的复制和基因型对其他病毒的复制没有影响。总之，在这组三重感染（HBV / HCV / HIV）队列中，发现了各种病毒类型。 HCV自发清除率很高，并且独立于HDV合并感染。在没有HBV治疗的情况下，HBV最常主动复制。 HBV / HCV复制或基因型与其他病毒的复制无关。

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