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首页> 外文期刊>AIDS Research and Human Retroviruses >Genotypic characterization and comparison of full-length envelope glycoproteins from South African HIV type 1 subtype C primary isolates that utilize CCR5 and/or CXCR4.
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Genotypic characterization and comparison of full-length envelope glycoproteins from South African HIV type 1 subtype C primary isolates that utilize CCR5 and/or CXCR4.

机译：利用CCR5和/或CXCR4的南非HIV 1型C亚型初级分离株的全长包膜糖蛋白的基因型鉴定和比较。

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摘要

CCR5 has preferentially been used by all circulating HIV-1 subtype C viruses for cell entry. Recently, we reported the highest proportion of CXCR4-utilizing primary isolates among a cohort of 20 South African AIDS patients. This study describes and compares the Env genotypic characteristics from these 20 HIV-1 subtype C (and unique CD recombinant) primary isolates. Fourteen primary isolates utilized CCR5, four (including the CD recombinant) used CXCR4, and two were dual tropic. Extensive analysis and comparison of important structural motifs such as the N-linked glycosylation sites, signal sequences, CD4-binding sites, variable loops, cleavage sites, known neutralizing antibody and small molecule inhibitor binding sites confirmed that other than the expected differences in the V3 loop, no sequence motifs distinguished between R5 and X4 tropism. Further correlation of the env genotype to functionally relevant motifs is necessary to elucidate the relationship between biologically and immunologically relevant sites and aid vaccine and novel drug design.
机译：所有流通的HIV-1 C型亚型病毒都优先使用CCR5进入细胞。最近，我们报道了在20名南非AIDS患者中，使用CXCR4的主要分离株比例最高。这项研究描述和比较了这20种HIV-1亚型C（和独特的CD重组）初级分离株的Env基因型特征。 14个初级分离株使用CCR5，4个（包括CD重组体）使用CXCR4，两个是双亲性的。广泛的分析和比较重要的结构基序，例如N-连接的糖基化位点，信号序列，CD4结合位点，可变环，切割位点，已知的中和抗体和小分子抑制剂结合位点，证实了V3的差异不同于预期环，没有区分R5和X4向性的序列基序。 env基因型与功能相关基序的进一步关联对于阐明生物学和免疫学相关位点之间的关系以及辅助疫苗和新药设计是必要的。

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