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首页> 外文期刊>AIDS Research and Human Retroviruses >Independent evolution of hypervariable regions of HIV-1 gp120: V4 as a swarm of N-Linked glycosylation variants.
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Independent evolution of hypervariable regions of HIV-1 gp120: V4 as a swarm of N-Linked glycosylation variants.

机译：HIV-1 gp120：V4高变区的独立进化，是一群N-连锁糖基化变体。

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In this study we have characterized intra-patient length polymorphism in V4 by cloning and sequencing a C2-C4 fragment from HIV plasma RNA in patients at different stages of HIV disease. Clonal analysis of clade B, G, and CRF02 isolates during early infection shows extensive intra-patient V4 variability, due to the presence of indel-associated polymorphism. Indels, coupled to amino acid substitution events, affect the number and distribution of potential N-glycosylation sites, resulting in the coexistence, within the same patient, of V4 subsets, each characterized by different sizes, amino acid sequences, and potential N-glycosylation patterns. In contrast, V3 appears to be relatively homogeneous, with similar V3 associated to significantly different V4 within the same clinical specimen. Based on these data, we propose that during early chronic infection V4 is present as a highly divergent quasispecies, enabling the virus to adopt different conformational structures according to immune constrains and other selective pressures.
机译：在这项研究中，我们通过对处于HIV疾病不同阶段的患者的HIV血浆RNA中的C2-C4片段进行克隆和测序，来表征V4中的患者体内长度多态性。早期感染过程中，进化枝B，G和CRF02分离株的克隆分析显示，由于indel相关多态性的存在，患者体内V4的变异性很大。插入缺失与氨基酸取代事件相关，影响潜在的N-糖基化位点的数量和分布，导致同一患者内V4亚群的共存，每个亚群的特征是大小，氨基酸序列和潜在的N-糖基化程度不同模式。相反，V3似乎是相对均质的，相似的V3与同一临床样本中明显不同的V4相关。根据这些数据，我们建议在早期慢性感染过程中，V4作为高度不同的准种存在，从而使病毒能够根据免疫限制和其他选择压力采用不同的构象结构。

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