Comparison of HIV type 1 sequences from plasma, cell-free breast milk, and cell-associated breast milk viral populations in treated and untreated women in Mozambique.

Andreotti M; Galluzzo CM; Guidotti G

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Comparison of HIV type 1 sequences from plasma, cell-free breast milk, and cell-associated breast milk viral populations in treated and untreated women in Mozambique.

机译：莫桑比克接受治疗和未经治疗的妇女血浆，无细胞母乳和与细胞相关的母乳病毒人群中HIV 1型序列的比较。

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We analyzed the sequences of the HIV viral populations obtained from plasma, cell-free breast milk, and breast milk cells of HAART-treated (23) and untreated (30) HIV-infected women to obtain information about the origin of the breast milk virus. Sequence analyses of viruses were performed using the TruGene HIV-1 assay. Direct sequences of the reverse transcriptase (RT) and protease (PR) genes were analyzed using the Phylip 3.68 suite of sequence analysis program and pairwise evolutionary distances were calculated with the Kimura two parameter model for estimation of distances. We found that the genetic distances between the plasma and the cell-free breast milk viruses and between the cell-free and cell-associated breast milk viruses for RT were higher in HAART-receiving women than in untreated women, suggesting viral evolution under selective drug pressure in breast milk. Our data support the hypothesis of the presence of an actively replicating viral population in the breast milk compartment, distinct from that present in plasma.

机译：我们分析了从血浆，无细胞母乳以及经HAART治疗的（23）和未经治疗（30）的HIV感染妇女的母乳细胞中获得的HIV病毒种群的序列，以获得有关母乳病毒起源的信息。使用TruGene HIV-1分析对病毒进行序列分析。使用Phylip 3.68序列分析程序套件分析逆转录酶（RT）和蛋白酶（PR）基因的直接序列，并使用Kimura两个参数模型计算成对进化距离，以估算距离。我们发现接受HAART的女性血浆和无细胞母乳病毒之间以及RT与无细胞和细胞相关的母乳病毒之间的遗传距离要比未经治疗的女性高，这表明在选择性药物作用下病毒的进化母乳中的压力。我们的数据支持这样的假设：在母乳区室中存在活跃复制的病毒种群，与血浆中存在的病毒种群不同。

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《AIDS Research and Human Retroviruses》 |2009年第7期|共5页
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Andreotti M; Galluzzo CM; Guidotti G;
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1. Comparison of HIV type 1 sequences from plasma, cell-free breast milk, and cell-associated breast milk viral populations in treated and untreated women in Mozambique. [J] . Andreotti M, Galluzzo CM, Guidotti G AIDS Research and Human Retroviruses . 2009,第7期

机译：莫桑比克接受治疗和未经治疗的妇女血浆，无细胞母乳和与细胞相关的母乳病毒人群中HIV 1型序列的比较。
2. Comparison of HIV Type 1 Sequences from Plasma, Cell-Free Breast Milk, and Cell-Associated Breast Milk Viral Populations in Treated and Untreated Women in Mozambique [J] . Mauro Andreotti, Clementina M. Galluzzo, Giovanni Guidotti, AIDS Research and Human Retroviruses . 2009,第7期

机译：莫桑比克接受治疗和未经治疗的妇女血浆，无细胞母乳和与细胞相关的母乳病毒人群中HIV 1型序列的比较
3. Minor drug-resistant HIV type-1 variants in breast milk and plasma of HIV type-1-infected Ugandan women after nevirapine single-dose prophylaxis. [J] . Pilger D, Hauser A, Kuecherer C, Antiviral therapy . 2011,第1期

机译：奈韦拉平单剂量预防后，在感染了1型艾滋病毒的乌干达妇女的母乳和血浆中存在较小的抗药性HIV 1型变异。
4. Structural and bio-molecular interactions in human tenascin C and HIV: An in silico approach to avert AIDS, for infants under the exposure of HIV: Computational approach for avertion of AIDS in infants by breast milk [C] . Sujay Ray, Arundhati Banerjee IEEE International Conference on Research in Computational Intelligence and Communication Networks . 2015

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5. Vitamin B-12 content of breast milk in deficient lactating Guatemalan women and effects of maternal supplementation on milk and infant status [D] . Deegan, Kathleen Lynn 2008

机译：哺乳期危地马拉妇女中母乳中的维生素B-12含量以及母体补充对母乳和婴儿状况的影响
6. Breast Milk from Tanzanian Women Has Divergent Effects on Cell-Free and Cell-Associated HIV-1 Infection In Vitro [O] . Magdalena A. Lyimo, Matilda Ngarina Mosi, Molly L. Housman, -1

机译：从坦桑尼亚妇女母乳对无细胞发散效应和细胞结合的HIV-1感染体外
7. Tumor necrosis factor-Î±, interleukin-10, and Î±-defensins in plasma and breast milk of HIV-infected highly active antiretroviral therapy-treated and untreated pregnant women in Mozambique [O] . Baroncelli S, Andreotti M, Guidotti G, 2008

机译：血浆和母乳中的肿瘤坏死因子-α，白介素10和α-防御素在莫桑比克的HIV感染的高活性抗逆转录病毒疗法治疗的和未治疗的孕妇

Comparison of HIV type 1 sequences from plasma, cell-free breast milk, and cell-associated breast milk viral populations in treated and untreated women in Mozambique.

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