CON4EI: Bovine Corneal Opacity and Permeability (BCOP) test for hazard identification and labelling of eye irritating chemicals (Reprinted from Toxicology in Vitro, vol 44C, pg 122-133)

Verstraelen Sandra; Maglennon Gareth; Hollanders Karen; Boonen Francis; Adriaens Els; Alepee Nathalie; Drzewiecka Agnieszka; Gruszka Katarzyna; Kandarova Helena; Willoughby Jamin A. Sr.; Guest Robert; Schofield Jane; Van Rompay An R.

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CON4EI: Bovine Corneal Opacity and Permeability (BCOP) test for hazard identification and labelling of eye irritating chemicals (Reprinted from Toxicology in Vitro, vol 44C, pg 122-133)

机译：CON4EI：牛角膜不透明度和渗透率（BCOP）试验危害识别和眼睛刺激性化学品的标记（从体外转载，Vol 44c，pg 122-133）

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Assessment of ocular irritation potential is an international regulatory requirement in the safety evaluation of industrial and consumer products. None in vitro ocular irritation assays are capable of fully categorizing chemicals as stand-alone. Therefore, the CEFIC-LRI-AIMT6-VITO CON4EI consortium assessed the reliability of eight in vitro test methods and computational models as well as established a tiered-testing strategy. One of the selected assays was Bovine Corneal Opacity and Permeability (BCOP). In this project, the same corneas were used for measurement of opacity using the OP-KIT, the Laser Light-Based Opacitometer (LLBO) and for histopathological analysis.

机译：对眼睛刺激潜力的评估是工业和消费产品安全评估中的国际监管要求。没有体外眼睛刺激测定能够将化学品完全分类为独立。因此，CEFIC-LRI-AIMT6-VITO CON4EI联盟评估了八种体外测试方法和计算模型的可靠性以及建立了一个分层测试策略。其中一种选择的测定是牛角膜不透明度和渗透性（BCOP）。在该项目中，使用OP-套件，激光基透明度计（LLBO）和组织病理学分析来使用相同的角膜来测量不透明度。

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来源
《Toxicology in vitro: an international journal published in association with BIBRA》 |2018年第2018期|共12页
作者
Verstraelen Sandra; Maglennon Gareth; Hollanders Karen; Boonen Francis; Adriaens Els; Alepee Nathalie; Drzewiecka Agnieszka; Gruszka Katarzyna; Kandarova Helena; Willoughby Jamin A. Sr.; Guest Robert; Schofield Jane; Van Rompay An R.;
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作者单位

VITO NV Flemish Inst Technol Res Boeretang 200 B-2400 Mol Belgium;

Envigo Huntingdon Cambs England;

VITO NV Flemish Inst Technol Res Boeretang 200 B-2400 Mol Belgium;

VITO NV Flemish Inst Technol Res Boeretang 200 B-2400 Mol Belgium;

Adriaens Consulting BVBA Aalter Belgium;

Oreal Res &

Innovat Aulnay Sous Bois France;

Inst Ind Organ Chem Branch Pszczyna Pszczyna Poland;

Inst Ind Organ Chem Branch Pszczyna Pszczyna Poland;

MatTek Vitro Life Sci Labs Bratislava Slovakia;

Cyprotex US LLC Northville MI USA;

Envigo Huntingdon Cambs England;

Envigo Huntingdon Cambs England;

VITO NV Flemish Inst Technol Res Boeretang 200 B-2400 Mol Belgium;

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原文格式 PDF
正文语种 eng
中图分类毒物学（毒理学）;
关键词
CON4EI; Ocular irritation; Bovine Comeal Opacity and Permeability (BCOP); OP-KIT; Laser Light-Based Opacitometer (LLBO); Histopathology; OECD Test Guideline 437;

机译：CON4EI;眼睛刺激;牛心碎和渗透率（BCOP）;OP-套件;基于激光的遮光剂（LLBO）;组织病理学;经合组织测试指南437;

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外文文献

1. CON4EI: Bovine Corneal Opacity and Permeability (BCOP) test for hazard identification and labelling of eye irritating chemicals (Reprinted from Toxicology in Vitro, vol 44C, pg 122-133) [J] . Verstraelen Sandra, Maglennon Gareth, Hollanders Karen, Toxicology in vitro: an international journal published in association with BIBRA . 2018,第期

机译：CON4EI：牛角膜不透明度和渗透率（BCOP）试验危害识别和眼睛刺激性化学品的标记（从体外转载，Vol 44c，pg 122-133）
2. CON4EI: Bovine Corneal Opacity and Permeability (BCOP) test for hazard identification and labelling of eye irritating chemicals [J] . Verstraelen Sandra, Maglennon Gareth, Hollanders Karen, Toxicology Letters: An International Journal Providing a Forum for Original and Pertinent Contributions in Toxicology Research . 2017,第S1期

机译：CON4EI：牛角膜不透明度和渗透率（BCOP）危害识别和眼睛刺激性化学品标记的试验
3. CON4EI: Selection of the reference chemicals for hazard identification and labelling of eye irritating chemicals (Reprinted from Toxicology in Vitro, vol 44C, pg 44-48) [J] . Adriaens E., Alepee N., Kandarova H., Toxicology in vitro: an international journal published in association with BIBRA . 2018,第期

机译：CON4EI：选择危险识别和眼睛刺激性化学品标记的参考化学品（从体外转载于毒理学，Vol 44c，Pg 44-48）
4. Laser Light-Based Opacitometer ‘Peira LLBO 180’: A new and validated opacitometer for use in the Bovine Corneal Opacity and Permeability (BCOP) eye irritation test method [O] . An R. Van Rompay, Els Adriaens, Sandra Verstraelen 2020

机译：基于激光的透光仪的佩纳拉LLBO 180：用于牛角膜不透明度和渗透率（BCOP）眼睛刺激试验方法的新且验证的不透明仪
5. Short Time Exposure (STE) test in conjunction with Bovine Corneal Opacity and Permeability (BCOP) assay including histopathology to evaluate correspondence with the Globally Harmonized System (GHS) eye irritation classification of textile dyes [O] . Oliveira Gisele Augusto Rodrigues, Ducas Rafael do Nascimento, Teixeira Gabriel Campos, 2015

机译：短时暴露（STE）测试与牛角膜不透明度和通透性（BCOP）分析相结合，包括组织病理学，以评估与纺织品染料的全球协调系统（GHS）眼睛刺激性分类的对应关系
6. Results of an In Vitro Test on Eye Corrosion/Severe Irritation: Bovine Corneal Opacity and Permeability (BCOP) Test with Amines, coco alkyldimethyl, N-oxides. [R] . 2015

机译：眼睛腐蚀/严重刺激的体外试验结果：用胺，椰油烷基二甲基，N-氧化物进行牛角膜不透明度和渗透性（BCOp）试验。

CON4EI: Bovine Corneal Opacity and Permeability (BCOP) test for hazard identification and labelling of eye irritating chemicals (Reprinted from Toxicology in Vitro, vol 44C, pg 122-133)

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