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首页> 外文期刊>Toxicology Letters: An International Journal Providing a Forum for Original and Pertinent Contributions in Toxicology Research >Long-term dose-dependent response of Mequindox on aldosterone, eorticosterone and five steroidogenic enzyme mRNAs in the adrenal of male rats
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Long-term dose-dependent response of Mequindox on aldosterone, eorticosterone and five steroidogenic enzyme mRNAs in the adrenal of male rats

机译：在雄性大鼠的肾上腺酮，高辛酮和五种类固醇酶MRNA上的Mequindox对Mequindox的长期剂量依赖性反应

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摘要

Mequindox (MEQ) is a synthetic quinoxaline 1,4-dioxides (QdNOs) derivative which can effectively improve growth and feed efficiency in animals. This study was to investigate the dose-dependent long-term toxicity in the adrenal of male rats exposed to 180 days of MEQ feed. Our data demonstrated that high doses of MEQ in the diet for 180 days led to adrenal damage and steroid hormone decrease, combined with sodium decrease and potassium increase in rat plasma. Significant changes of GSH and SOD in plasma were observed in the high doses (110,275 mg/kg) groups. At the same doses, MEQ. treatment down-regulated the mRNA levels of CYP11A1, CYP11B1 and CYP11B2 which located in mitochondria, but up-regulated mRNA levels of CYP21 and 3beta-HSD which located in endoplasmic reticulum. In conclusion, we reported the dose-dependent long-term toxicity of MEQ on adrenal gland in male rats, which raise awareness of its toxic effects to animals and consumers, and its mechanism may involve in oxidative stress and steroid hormone biosynthesis pathway.
机译：MEQUINDOX（MEQ）是一种合成喹喔啉1,4-二氧化氧化物（QDNOS）衍生物，可有效提高动物的生长和饲料效率。本研究是调查暴露于180天的阳性大鼠肾上腺剂的剂量依赖性的长期毒性。我们的数据显示，饮食中的高剂量MEQ为180天导致肾上腺损伤和类固醇激素减少，与大鼠等离子体的钠降低和钾增加。在高剂量（110,275mg / kg）基团中观察到血浆中GSH和SOD的显着变化。以同样的剂量，meq。处理下调位于线粒体的CYP11A1，CYP11B1和CYP11B2的MRNA水平，但位于内质网中的CYP21和3β-HSD的上调​​mRNA水平。总之，我们报道了雄性大鼠肾上腺肾上腺的剂量依赖性长期毒性，这提高了对动物和消费者的毒性作用的认识，其机制可能涉及氧化应激和类固醇激素生物合成途径。

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