An in vitro investigation on the cytotoxic and nuclear receptor transcriptional activity of the mycotoxins fumonisin B1 and beauvericin

Fernandez-Blanco Celia; Frizzell Caroline; Shannon Maeve; Ruiz Maria-Jose; Connolly Lisa

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An in vitro investigation on the cytotoxic and nuclear receptor transcriptional activity of the mycotoxins fumonisin B1 and beauvericin

机译：霉菌毒素Fumonisin B1和Beaumericin的细胞毒性和核受体转录活性的体外研究

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Fumonisin B1 (FB1) and beauvericin (BEA) are secondary metabolites of filamentous fungi, which under appropriate temperature and humidity conditions may develop on various foods and feeds. To date few studies have been performed to evaluate the toxicological and endocrine disrupting effects of FB1 and BEA. The present study makes use of various in vitro bioassays including; oestrogen, androgen, progestagen and glucocorticoid reporter gene assays (RGAs) for the study of nuclear receptor transcriptional activity, the thiazolyl blue tetrazolium bromide (MTT) assay to monitor cytotoxicity and high content analysis (HCA) for the detection of pre-lethal toxicity in the RGA and Caco-2 human colon adenocarcinoma cells.

机译：Fumonisin B1（FB1）和Beauvericin（BEA）是丝状真菌的次级代谢物，其在适当的温度和湿度条件下可能在各种食品和饲料上产生。迄今为止，已经进行了若干研究以评估FB1和BEA的毒理学和内分泌破坏效果。本研究利用各种体外生物测定，包括; 雌激素，雄激素，孕酮和糖皮质激素报告基因测定（RGA）用于研究核受体转录活性，噻唑基蓝四唑溴铵（MTT）测定监测细胞毒性和高含量分析（HCA），用于检测致致致命毒性 RGA和Caco-2人结肠腺癌细胞。

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来源
《Toxicology Letters: An International Journal Providing a Forum for Original and Pertinent Contributions in Toxicology Research》 |2016年第null期|共10页
作者
Fernandez-Blanco Celia; Frizzell Caroline; Shannon Maeve; Ruiz Maria-Jose; Connolly Lisa;
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作者单位

Univ Valencia Fac Pharm Toxicol Lab Av Vicent Andres Estelles S-N E-46100 Valencia Spain;

Queens Univ Sch Biol Sci Inst Global Food Secur Belfast Antrim North Ireland;

Queens Univ Sch Biol Sci Inst Global Food Secur Belfast Antrim North Ireland;

Univ Valencia Fac Pharm Toxicol Lab Av Vicent Andres Estelles S-N E-46100 Valencia Spain;

Queens Univ Sch Biol Sci Inst Global Food Secur Belfast Antrim North Ireland;

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原文格式 PDF
正文语种 eng
中图分类毒物学（毒理学）;
关键词
Mycotoxin; Beauvericin; Fumonisin B1; Endocrine disruptor; Reporter gene assay; High Content Analysis;

机译：霉菌毒素;Beauvericin;Fumonisin B1;内分泌破坏器;报告基因测定;高内容分析;

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1. An in vitro investigation on the cytotoxic and nuclear receptor transcriptional activity of the mycotoxins fumonisin B1 and beauvericin [J] . Fernandez-Blanco Celia, Frizzell Caroline, Shannon Maeve, Toxicology Letters: An International Journal Providing a Forum for Original and Pertinent Contributions in Toxicology Research . 2016,第Null期

机译：霉菌毒素伏马毒素B1和紫杉醇的细胞毒性和核受体转录活性的体外研究
2. Effects of the mycotoxin patulin at the level of nuclear receptor transcriptional activity and steroidogenesis in vitro [J] . FrizzellC., ElliottC.T., ConnollyL. Toxicology Letters: An International Journal Providing a Forum for Original and Pertinent Contributions in Toxicology Research . 2014,第2期

机译：真菌毒素棒曲蛋白对核受体转录活性和类固醇生成的影响
3. A nuclear factor I-like activity and a liver-specific repressor govern estrogen-regulated in vitro transcription from the Xenopus laevis vitellogenin B1 promoter. [J] . B Corthésy, J R Cardinaux, F X Claret, Molecular and Cellular Biology . 1989,第12期

机译：核因子I样活性和肝特异性阻遏物控制雌激素从非洲爪蟾卵黄蛋白原B1启动子的体外转录。
4. Transcriptional Regulatory Mechanismsof the Human ApoA-I/ApoCIII GeneCluster in vitro and in Trangenic Mice:The Role of Nuclear Receptors [C] . World Association for Laser Therapy . 2002

机译：体外和长核小鼠的人apoa-i / apociii genecluster的转录调节机制：核受体的作用
5. Fumonisin B1 toxicity in swine: A comparative analysis of genetically engineered Bt corn and non-Bt corn by using quantitative dietary exposure assessment modeling and ecotoxicological investigations on earthworms. [D] . Delgado, James Edward. 2014

机译：伏马菌素B1对猪的毒性：通过定量饮食暴露评估模型和on生态毒理学研究，对转基因Bt玉米和非Bt玉米进行比较分析。
6. A nuclear factor I-like activity and a liver-specific repressor govern estrogen-regulated in vitro transcription from the Xenopus laevis vitellogenin B1 promoter. [O] . B Corthésy, J R Cardinaux, F X Claret, 1989

机译：象核仁因子一样的活性和肝特异性阻遏物控制雌激素从非洲爪蟾卵黄蛋白原B1启动子的体外转录。
7. An in vitro investigation on the cytotoxic and nuclear receptor transcriptional activity of the mycotoxins fumonisin B1 and beauvericin [O] . Fernández-Blanco Celia, Frizzell Caroline, Shannon Maeve, 2016

机译：霉菌毒素伏马毒素B1和紫杉醇的细胞毒性和核受体转录活性的体外研究
8. Investigation of T-2 Mycotoxin-Induced Cytotoxicity In Vitro and Protective Effects of Flavonoid Compounds [R] . Markham, R. J. F., DiNinno, V. L., Erhardt, N. P., 1986

机译：T-2霉菌毒素诱导体外细胞毒性及黄酮类化合物保护作用的研究

An in vitro investigation on the cytotoxic and nuclear receptor transcriptional activity of the mycotoxins fumonisin B1 and beauvericin

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